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Displaying results 571 - 580 of 1804 in total
  1. Target

    Retinoic acid receptor beta

    go.drugbank.com/bio_entities/BE0000206
    TargetHumans

    Receptor for retinoic acid.

    Polypeptides: Retinoic acid receptor betaSynonyms: Nuclear receptor subfamily 1 group B member 2
  2. Target

    Muscarinic acetylcholine receptor M5

    go.drugbank.com/bio_entities/BE0000247
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M5Function: G protein-coupled acetylcholine receptor activity
  3. Target

    Alpha-2C adrenergic receptor

    go.drugbank.com/bio_entities/BE0000342
    TargetHumans

    Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (...

    Polypeptides: Alpha-2C adrenergic receptorSynonyms: Alpha-2 adrenergic receptor subtype C4
  4. Target

    5-hydroxytryptamine receptor 2B

    go.drugbank.com/bio_entities/BE0000393
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600). … Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538, PubMed:30127358, PubMed:36087581).

    Polypeptides: 5-hydroxytryptamine receptor 2BSynonyms: Serotonin receptor 2B
  5. Target

    Somatostatin receptor type 1

    go.drugbank.com/bio_entities/BE0000452
    TargetHumans

    Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. … In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins

    Polypeptides: Somatostatin receptor type 1
  6. Target

    5-hydroxytryptamine receptor 1F

    go.drugbank.com/bio_entities/BE0000460
    TargetHumans

    Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed:34239069). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed

    Polypeptides: 5-hydroxytryptamine receptor 1FSynonyms: Serotonin receptor 1F
  7. Target

    5-hydroxytryptamine receptor 1E

    go.drugbank.com/bio_entities/BE0000476
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731).

    Polypeptides: 5-hydroxytryptamine receptor 1ESynonyms: Serotonin receptor 1E
  8. Target

    Low-density lipoprotein receptor

    go.drugbank.com/bio_entities/BE0000499
    TargetCarrierHumans

    In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

    Polypeptides: Low-density lipoprotein receptorSynonyms: LDL receptor
  9. Target

    Extracellular calcium-sensing receptor

    go.drugbank.com/bio_entities/BE0000509
    TargetHumans

    Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (PubMed:32843625). … full receptor activation (PubMed:27386547, PubMed:27434672, PubMed:32817431, PubMed:33603117, PubMed:34194040).

    Polypeptides: Extracellular calcium-sensing receptorSynonyms: Parathyroid cell calcium-sensing receptor 1
  10. Target

    5-hydroxytryptamine receptor 2C

    go.drugbank.com/bio_entities/BE0000533
    TargetHumans

    Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:12970106, PubMed:18703043, PubMed:19057895, PubMed:29398112, PubMed:7895773).

    Polypeptides: 5-hydroxytryptamine receptor 2CSynonyms: Serotonin receptor 2C, 5-hydroxytryptamine receptor 1C