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Displaying results 51 - 60 of 166 in total
  1. Target

    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0018277
    TargetHumans

    Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)

    Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1
  2. Target

    Nuclear cap-binding protein subunit 1

    go.drugbank.com/bio_entities/BE0014101
    TargetHumans

    The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and … NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858)

    Synonyms: NCBP 80 kDa subunit, 80 kDa nuclear cap-binding protein
  3. Target

    Diacylglycerol kinase alpha

    go.drugbank.com/bio_entities/BE0002324
    TargetHumans

    Also plays an important role in the biosynthesis of complex lipids (Probable). … Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:2175712).

    Synonyms: 80 kDa diacylglycerol kinase
  4. Target

    Myristoylated alanine-rich C-kinase substrate

    go.drugbank.com/bio_entities/BE0012891
    TargetHumans

    Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or … Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation.

    Synonyms: Protein kinase C substrate, 80 kDa protein, light chain
  5. Target

    Interleukin-6 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0002859
    TargetHumans

    Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. … The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells

    Synonyms: Membrane glycoprotein 80
  6. Target

    Adiponectin receptor

    go.drugbank.com/bio_entities/BE0010287
    TargetHumans

    Required for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.

    Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I
  7. Target

    Immunoglobulin J chain

    go.drugbank.com/bio_entities/BE0009083
    TargetHumans

    In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers.

    Synonyms: Joining chain of multimeric IgA and IgM
  8. Target

    Interleukin enhancer-binding factor 3

    go.drugbank.com/bio_entities/BE0014107
    TargetHumans

    As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. … Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398).

    Synonyms: Translational control protein 80
  9. Target

    Prolyl 3-hydroxylase OGFOD1

    go.drugbank.com/bio_entities/BE0002210
    TargetHumans

    Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation

    Synonyms: Termination and polyadenylation 1 homolog, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
  10. Target

    Complement C5

    go.drugbank.com/bio_entities/BE0000855
    TargetHumans

    Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that … Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279)

    Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4