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Bupivacaine Action Pathway
smpdb.ca/view/SMP0000393Drug actionBupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Bupivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is proton...
Chloroprocaine Action Pathway
smpdb.ca/view/SMP0000394Drug actionChloroprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Chloroprocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is ...
Proparacaine Action Pathway
smpdb.ca/view/SMP0000403Drug actionProparacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Proparacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is prot...
Oxymorphone Action Pathway
smpdb.ca/view/SMP0000412Drug actionOxymorphone (also known as Numorphan) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular cAMP by inh...
Carfentanil Action Pathway
smpdb.ca/view/SMP0000414Drug actionCarfentanil (also known as carfentanyl or Wildnil) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellula...
Remifentanil Action Pathway
smpdb.ca/view/SMP0000416Drug actionRemifentanil is a pharmacologically-active, synthetic, small molecule derived from fentanyl and belongs to a class of drugs called opioids. Opioids are therapeutically employed to achieve analgesia. Remifentanial’s rapid mechanism of act...
Diphenoxylate Action Pathway
smpdb.ca/view/SMP0000675Drug actionDiphenoxylate (also known as Difenossilato or Lomotil) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracel...
Levomethadyl Acetate Action Action Pathway
smpdb.ca/view/SMP0000677Drug actionLevomethadyl acetate (also known as LAAM) is a synthetic synthetic opioid analgesic with multiple actions quantitatively similar to those as morphine, the most prominent of which involve the central nervous system and organs composed of ...
Dimethylthiambutene Action Pathway
smpdb.ca/view/SMP0000680Drug actionDimethylthiambutene (also known as Ohton or Aminobutene) is an opioid analgesic and substrate for mu-type opioid receptor which can be used for relieving pain. Dimethylthiambutene can act on mu-opiod receptor on neurons located at centra...
Alvimopan Action Pathway
smpdb.ca/view/SMP0000685Drug actionAlvimopan is prescribed to treat patient opioid-induced constipation, a common side effect of opioid therapy. This side effect results in delayed discharge for hospitalized patients following surgery. Alvimopan helps to increase gastroin...