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Displaying results 6081 - 6090 of 10000 in total
  1. Target

    Glycogenin-1

    go.drugbank.com/bio_entities/BE0004498
    TargetHumans

    It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction

    Polypeptides: Glycogenin-1Synonyms: GN-1
  2. Target

    Anoctamin-1

    go.drugbank.com/bio_entities/BE0004746
    TargetHumans

    Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the int...

    Polypeptides: Anoctamin-1Synonyms: Discovered on gastrointestinal stromal tumors protein 1
  3. Target

    Peroxiredoxin-1

    go.drugbank.com/bio_entities/BE0005844
    TargetEnzymeHumans

    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor o...

    Polypeptides: Peroxiredoxin-1Synonyms: Thioredoxin-dependent peroxiredoxin 1
  4. Target

    Glypican-1

    go.drugbank.com/bio_entities/BE0008217
    TargetBos taurus

    Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversi...

    Polypeptides: Glypican-1
  5. Target

    Calsequestrin-1

    go.drugbank.com/bio_entities/BE0008699
    TargetHumans

    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues at the protein surface, often at t...

    Polypeptides: Calsequestrin-1
  6. Target

    Beclin-1

    go.drugbank.com/bio_entities/BE0009015
    TargetHumans

    Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidyl...

    Polypeptides: Beclin-1
  7. Target

    Pappalysin-1

    go.drugbank.com/bio_entities/BE0009031
    TargetHumans

    Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. … Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF

    Polypeptides: Pappalysin-1
  8. Target

    Exportin-1

    go.drugbank.com/bio_entities/BE0009694
    TargetHumans

    Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase ...

    Polypeptides: Exportin-1Synonyms: Chromosome region maintenance 1 protein homolog
  9. Target

    Prohibitin 1

    go.drugbank.com/bio_entities/BE0009786
    TargetHumans

    Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcrip...

    Polypeptides: Prohibitin 1
  10. Target

    Syndecan-1

    go.drugbank.com/bio_entities/BE0010357
    TargetHumans

    Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660...

    Polypeptides: Syndecan-1