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Displaying results 6161 - 6170 of 10000 in total
  1. Target

    Semenogelin-1

    go.drugbank.com/bio_entities/BE0005833
    TargetHumans

    Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the ...

    Polypeptides: Semenogelin-1
  2. Target

    Nucleobindin-1

    go.drugbank.com/bio_entities/BE0008700
    TargetHumans

    Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding ...

    Polypeptides: Nucleobindin-1
  3. Target

    Caveolin-1

    go.drugbank.com/bio_entities/BE0010471
    TargetHumans

    May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1...

    Polypeptides: Caveolin-1
  4. Target

    Angiopoietin-1

    go.drugbank.com/bio_entities/BE0010681
    TargetHumans

    Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading,...

    Polypeptides: Angiopoietin-1Synonyms: ANG-1
  5. Target

    Presenilin-1

    go.drugbank.com/bio_entities/BE0010960
    TargetHumans

    Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:1...

    Polypeptides: Presenilin-1Synonyms: PS-1
  6. Target

    Gremlin-1

    go.drugbank.com/bio_entities/BE0011799
    TargetHumans

    Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 ...

    Polypeptides: Gremlin-1Synonyms: Cysteine knot superfamily 1, BMP antagonist 1
  7. Target

    Claudin-1

    go.drugbank.com/bio_entities/BE0012196
    TargetHumans

    Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the perm...

    Polypeptides: Claudin-1
  8. Target

    Deoxyribonuclease-1

    go.drugbank.com/bio_entities/BE0012829
    TargetHumans

    Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:11241278, PubMed:2251263, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By sim...

    Polypeptides: Deoxyribonuclease-1
  9. Target

    Dynamin-1

    go.drugbank.com/bio_entities/BE0013996
    TargetHumans

    Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (...

    Polypeptides: Dynamin-1
  10. Target

    Sequestosome-1

    go.drugbank.com/bio_entities/BE0014160
    TargetHumans

    May regulate the activation of NFKB1 by TNF, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284).

    Polypeptides: Sequestosome-1