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Displaying results 611 - 620 of 10000 in total
  1. Pathway

    Metabolism and Physiological Effects of N-Acetyl-1-Methylhistidine

    smpdb.ca/view/SMP0126802
    Metabolic

    Histidine and derivatives are compounds containing histidine or a derivative thereof resulting from a reaction of histidine at the amino group or the carboxy group, or from the replacement of any hydrogen … N-Acetyl-1-methylhistidine is an acetylated derivative of 1-methylhistidine and a very strong basic compound (based on its pKa).

    Drugs: Histidine · Ademetionine · 1-Methylhistidine
  2. Pathway

    Excitatory Neural Signalling Through 5-HTR 6 and Serotonin

    smpdb.ca/view/SMP0000312
    Signaling

    The 5-HT6 receptor is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
  3. Pathway

    Metabolism and Physiological Effects of Trimethylamine N-oxide (TMAO)

    smpdb.ca/view/SMP0123192
    Metabolic

    Trimethylamine N-oxide(TMAO) is a uremic toxin compound that can be metabolized from dietary choline. There are 2 metabolic reactions that occur in order to get TMAO. … First choline obtained from choline rich foods such as eggs or meat enter the gut and get metabolized to trimethylamine by gut microbes.

    Drugs: Choline · Flavin adenine dinucleotide
  4. Pathway

    Metabolism and Physiological Effects of N-Acetyl-L-Alanine

    smpdb.ca/view/SMP0126554
    Metabolic

    N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins. … Individuals with aminoacylase I deficiency will experience convulsions, hearing loss and difficulty feeding. Many N-acetylamino acids, including N-acetylalanine, are classified as uremic toxins.

    Drugs: Alanine
  5. Drug

    Etomidate

    go.drugbank.com/drugs/DB00292
    ApprovedInvestigational

    Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.

    Categories: Hypnotics and SedativesProducts: ETOMIDATE-LIPURO 20MG/10ML INJ IN 10ML GA, ETOMIDE LIPURO 20MG/10ML IV ENJEKSIYONLUK EMULSIYON ICEREN AMPUL, 10 ADET
  6. Drug

    Cefuroxime

    go.drugbank.com/drugs/DB01112
    ApprovedInvestigational

    It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.

    Categories: cefuroxime and metronidazoleProducts: Cefuroxime and Dextrose, Kefurox Inj Pws 1.5gm/add-vantage Vial
  7. Drug

    Carbidopa

    go.drugbank.com/drugs/DB00190
    ApprovedInvestigational

    [T394] The first approved product by the FDA containing only carbidopa was developed by Amerigens Pharmaceuticals Ltd and approved on 2014. … [L5110] On the other hand, the combination treatment of carbidopa/levodopa was originally developed by Watson Labs but the historical information by the FDA brings back to the approval of this combination

    Mixtures: ISICOM 100MG/25MG, ISICOM 100MG/25MGProducts: Carbidopa and Levodopa, Carbidopa and levodopa
  8. Drug

    Tenecteplase

    go.drugbank.com/drugs/DB00031
    ApprovedInvestigational

    Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). … It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids

    Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansProducts: METALYSE®10.000 U (50MG) POLVO LIOFILIZADO PARA SOLUCION INYECTABLE, METALYSE FOR INJECTION 10,000 u/vial
  9. Drug

    Methocarbamol

    go.drugbank.com/drugs/DB00423
    ApprovedInvestigationalVet approved

    [L6295] A combination product with [acetylsalicylic acid] and [codeine] is available in Canada by prescription.[L6295] Methocarbamol was FDA approved on 16 July 1957.[L6265] … [A178450] Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts

    Mixtures: Acetaminophen 325mg + Methocarbamol 400mg Caplets, Methocarbamol and AspirinProducts: Robaxin Inj 100mg/ml, METOCARBAMOL 1G/10ML
  10. Drug

    Cabergoline

    go.drugbank.com/drugs/DB00248
    ApprovedInvestigational

    Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome.

    Categories: Ergot Alkaloids and Derivatives, Genito Urinary System and Sex HormonesProducts: CABASERIL 2MG, CABERGOLIN TEVA 2MG