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Displaying results 6201 - 6210 of 10000 in total
  1. Target

    2-Hydroxyacid oxidase 1

    go.drugbank.com/bio_entities/BE0003766
    TargetEnzymeHumans

    Is not active on L-lactate and 2-hydroxybutanoate (PubMed:10777549) … Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency (PubMed:10777549, PubMed:17669354

    Polypeptides: 2-Hydroxyacid oxidase 1Function: (S)-2-hydroxy-acid oxidase activity
  2. Target

    2-aminobenzoylacetyl-CoA thioesterase

    go.drugbank.com/bio_entities/BE0003865
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2-aminobenzoylacetate (2-ABA), the precursor of HHQ. … Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important

    Polypeptides: 2-aminobenzoylacetyl-CoA thioesterase
  3. Target

    Dihydrofolate reductase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0004001
    TargetHumans

    Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR

    Polypeptides: Dihydrofolate reductase 2, mitochondrial
  4. Target

    Arylacetamide deacetylase-like 2

    go.drugbank.com/bio_entities/BE0004098
    TargetHumans

    Polypeptides: Arylacetamide deacetylase-like 2
  5. Target

    Protein spire homolog 2

    go.drugbank.com/bio_entities/BE0004157
    TargetHumans

    Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskel...

    Polypeptides: Protein spire homolog 2Synonyms: Spir-2
  6. Target

    Penicillin-binding protein 2

    go.drugbank.com/bio_entities/BE0004180
    TargetStaphylococcus aureus (strain COL)

    Polypeptides: Penicillin-binding protein 2
  7. Target

    Actin-related protein 2

    go.drugbank.com/bio_entities/BE0004250
    TargetHumans

    ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin ne...

    Polypeptides: Actin-related protein 2Synonyms: Actin-like protein 2
  8. Target

    SMAD family member 2

    go.drugbank.com/bio_entities/BE0004445
    TargetHumans

    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter regio...

    Polypeptides: SMAD family member 2Synonyms: hMAD-2, SMAD 2
  9. Target

    Adenylate kinase 2, mitochondrial

    go.drugbank.com/bio_entities/BE0004477
    TargetEnzymeHumans

    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of t...

    Polypeptides: Adenylate kinase 2, mitochondrialSynonyms: AK 2, ATP-AMP transphosphorylase 2
  10. Target

    Sterol O-acyltransferase 2

    go.drugbank.com/bio_entities/BE0004608
    TargetEnzymeHumans

    Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:11294643, PubMed:16647063). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:11294643)....

    Polypeptides: Sterol O-acyltransferase 2Synonyms: ACAT-2, Cholesterol acyltransferase 2