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Displaying results 671 - 680 of 2674 in total
  1. Target

    Interferon gamma receptor 2

    go.drugbank.com/bio_entities/BE0000467
    TargetHumans

    Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114) … Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:7673114, PubMed:8124716).

    Polypeptides: Interferon gamma receptor 2Synonyms: IFN-gamma receptor 2, Interferon gamma receptor beta-chain
  2. Target

    Alpha-1A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000501
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1A adrenergic receptorSynonyms: Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c
  3. Target

    Kappa-type opioid receptor

    go.drugbank.com/bio_entities/BE0000632
    TargetHumans

    G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. … Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A.

    Polypeptides: Kappa-type opioid receptorFunction: dynorphin receptor activity
  4. Target

    Activin receptor type-1B

    go.drugbank.com/bio_entities/BE0000665
    TargetHumans

    Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). … Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B.

    Polypeptides: Activin receptor type-1BSynonyms: Activin receptor type IB, Activin receptor-like kinase 4
  5. Target

    Alpha-1D adrenergic receptor

    go.drugbank.com/bio_entities/BE0000715
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1D adrenergic receptorSynonyms: Alpha-1A adrenergic receptor, Alpha-adrenergic receptor 1a
  6. Target

    Metabotropic glutamate receptor 2

    go.drugbank.com/bio_entities/BE0000974
    TargetHumans

    Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794).

    Polypeptides: Metabotropic glutamate receptor 2
  7. Target

    Insulin receptor substrate 1

    go.drugbank.com/bio_entities/BE0000977
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045 … Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of

    Polypeptides: Insulin receptor substrate 1Function: insulin receptor binding
  8. Target

    Toll-like receptor 9

    go.drugbank.com/bio_entities/BE0001171
    TargetHumans

    Key component of innate and adaptive immunity (PubMed:14716310). TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms (PubMed:14716310). TLR9 is a ...

    Polypeptides: Toll-like receptor 9Function: interleukin-1 receptor binding
  9. Target

    Somatostatin receptor type 5

    go.drugbank.com/bio_entities/BE0002147
    TargetHumans

    Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

    Polypeptides: Somatostatin receptor type 5
  10. Target

    Toll-like receptor 4

    go.drugbank.com/bio_entities/BE0002442
    TargetHumans

    Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream … In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86 (PubMed:23880187).

    Polypeptides: Toll-like receptor 4