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Displaying results 61 - 70 of 5418 in total
  1. Target

    Spike glycoprotein

    go.drugbank.com/bio_entities/BE0010022
    TargetSARS-CoV-2

    The stalk domain of S contains three hinges, giving the head unexpected orientational freedom (PubMed:32817270).

    Synonyms: S glycoprotein
  2. Target

    Anamorsin homolog

    go.drugbank.com/bio_entities/BE0009259
    TargetPlasmodium falciparum (isolate 3D7)

    Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. … Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.

    Synonyms: Fe-S cluster assembly protein DRE2 homolog
  3. Target

    Adenosylhomocysteinase

    go.drugbank.com/bio_entities/BE0001684
    TargetHumans

    Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity)

    Synonyms: S-adenosyl-L-homocysteine hydrolase
  4. Target

    Cytosol aminopeptidase

    go.drugbank.com/bio_entities/BE0003882
    TargetHumans

    For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. … Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status

    Synonyms: Peptidase S, Cysteinylglycine-S-conjugate dipeptidase
  5. Target

    Protein S100-B

    go.drugbank.com/bio_entities/BE0001177
    TargetHumans

    Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:20950652, PubMed:6487634). Weakly binds calcium but binds zinc very tightly-di...

    Synonyms: S-100 protein beta chain, S-100 protein subunit beta
  6. Target

    Protein S100-A1

    go.drugbank.com/bio_entities/BE0001090
    TargetHumans

    Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) l...

    Synonyms: S-100 protein alpha chain, S-100 protein subunit alpha
  7. Target

    Adenosylhomocysteinase

    go.drugbank.com/bio_entities/BE0009225
    TargetPlasmodium falciparum (isolate 3D7)

    Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via

    Synonyms: S-adenosyl-L-homocysteine hydrolase
  8. Target

    Glyceraldehyde-3-phosphate dehydrogenase

    go.drugbank.com/bio_entities/BE0000542
    TargetHumans

    Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)

    Synonyms: Peptidyl-cysteine S-nitrosylase GAPDH
  9. Target

    Glutathione synthetase

    go.drugbank.com/bio_entities/BE0000185
    TargetHumans

    Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in li...

    Synonyms: GSH-S
  10. Target

    Puromycin-sensitive aminopeptidase

    go.drugbank.com/bio_entities/BE0003419
    TargetHumans

    Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway f...

    Synonyms: AAP-S