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Edrophonium Action Pathway (new)
smpdb.ca/view/SMP0126690Drug actionEdrophonium is a cholinesterase inhibitor used in the treatment of myasthenia gravis, that works to prolong the duration of action of acetylcholine. The drug acts rapidly by binding to acetylcholinesterase and cholinesterase halting the ...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FDistigmine Action Pathway
smpdb.ca/view/SMP0126700Drug actionDistigmine is a cholinesterase inhibitor, a parasympathomimetic agent used in the treatment of neurogenic bladder dysfunction and or myasthenia gravis. This is an experimental drug that acts by inhibiting cholinesterase and also binds di...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FCarbaryl Action Pathway
smpdb.ca/view/SMP0126728Drug actionCarbaryl is an insecticide in addition to a cholinesterase inhibitor it is used as a treatment to remove head lice. It acts on insects and due to its relative dosage compared to a human, the lice having their acetylcholinesterase inhibit...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FMethylphosphinic Acid Action Pathway
smpdb.ca/view/SMP0126733Drug actionMethylphosphinic acid is an experimental drug being tested to be a possible cholinesterase inhibitor, as it appears to inhibit the breakdown of acetylcholine. Further research needs to be conducted in order to confirm results, safety and...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FNateglinide Action Pathway
smpdb.ca/view/SMP0000453Drug actionDepolarization causes opening of voltage-gated calcium channels, allowing calcium to enter cell. High intracellular calcium subsequently stimulate vesicle exocytosis and insulin secretion.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Gliquidone Action Pathway
smpdb.ca/view/SMP0126143Drug actionIn consequence, the depolarization stimulates the calcium ion influx through voltage-sensitive calcium channels. … This action increases the intracellular calcium ion concentration and then induces the secretion of insulin (by exocytosis). The ATP-sensitive potassium channel is a hetero-octameric protein.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Tolbutamide Action Pathway
smpdb.ca/view/SMP0126155Drug actionIn consequence, it causes an influx of calcium ions thus releasing the insulin-containing granules by exocytosis.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Hydroxyzine H1 Antihistamine Neurological Sleep Action Pathway
smpdb.ca/view/SMP0145414Drug actionHydroxyzine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interf...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1BMepyramine H1 Antihistamine Neurological Sleep Action Pathway
smpdb.ca/view/SMP0145417Drug actionMepyramine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfe...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1BBromodiphenhydramine H1 Antihistamine Neurological Sleep Action Pathway
smpdb.ca/view/SMP0145421Drug actionBromodiphenhydramine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamin...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1B