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Paliperidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126592Drug actionPaliperidone is the primary active metabolite of risperidone. The two antipsychotics are also metabolized differently, as risperidone is metabolized in the liver mainly by the polymorphic cytochrome P450 2D6 (CYP2D6) to its active metabo...
Quetiapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126827Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Desvenlafaxine SNRI - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126423Drug actionThe exact mechanism of action of venlafaxine in the treatment of various psychiatric conditions has not been fully elucidated; however, it is understood that venlafaxine and its active metabolite O-desmethylvenlafaxine (ODV) potently and...
Ziprasidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126472Drug actionZiprasidone is an atypical antipsychotic used to treat schizophrenia, bipolar mania, and acute agitation in schizophrenic patients. It also indicated improvement on the manic syndrome subscale that measures symptoms of mania such as mood...
Chlorpromazine - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126485Drug actionProchlorperazine and chlorpromazine are examples of this class of Phenothiazines. Phenothiazines antagonize the D2 receptor, most notably in the area postrema in the brain. IV, PO, and rectal (PR) formulations are available. Side effects...
Triflupromazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126491Drug actionTriflupromazine is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can a...
Fluphenazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126501Drug actionFluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behavioural complications in patients ...
Lurasidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126526Drug actionLurasidone is is a benzothiazol derivative and an atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Lurasidone is an atypical antipsychotic that is a D2 and 5-HT2A (mixed serot...
Perphenazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126530Drug actionPerphenazine is a piperazinyl phenothiazine first generation antipsychotic that acts on the central nervous system, and has a greater behavioral potency than other phenothiazine derivatives whose side chains do not contain a piperazine m...
Prochlorperazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126604Drug actionProchlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Dopamine-antagonizing medications such as prochlorperazine are thoug...
Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Prochlorperazine · Dopamine · Levodopa +2 more