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Sodium-coupled neutral amino acid transporter 3
go.drugbank.com/bio_entities/BE0000285TargetTransporterHumansSymporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). … The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827).
Polypeptides: Sodium-coupled neutral amino acid transporter 3Sodium channel protein type 4 subunit alpha
go.drugbank.com/bio_entities/BE0002083TargetTransporterHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes.
Polypeptides: Sodium channel protein type 4 subunit alphaSynonyms: Sodium channel protein type IV subunit alpha, Sodium channel protein skeletal muscle subunit alphaSodium/potassium-transporting ATPase subunit beta-2
go.drugbank.com/bio_entities/BE0005018TransporterTargetHumansThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-2Synonyms: Sodium/potassium-dependent ATPase subunit beta-2Farnesyl pyrophosphate synthase
go.drugbank.com/bio_entities/BE0000776TargetHumansCatalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product … FPP also serves as substrate for protein farnesylation and geranylgeranylation.
Polypeptides: Farnesyl pyrophosphate synthaseC55-isoprenyl pyrophosphate
go.drugbank.com/bio_entities/BE0004829TargetGram positive and gram negative bacteriaGeranylgeranyl pyrophosphate synthase
go.drugbank.com/bio_entities/BE0003570TargetHumansCatalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins
Polypeptides: Geranylgeranyl pyrophosphate synthaseSodium/potassium-transporting ATPase subunit alpha-1
go.drugbank.com/bio_entities/BE0000732TargetEnzymeTransporterHumansCould also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity … This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function.
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-1Synonyms: Sodium pump subunit alpha-1ATP synthase subunit c, sodium ion specific
go.drugbank.com/bio_entities/BE0001846TargetPropionigenium modestumF-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane sodium channel, linked together by a central stalk and a peripheral … F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient.
Polypeptides: ATP synthase subunit c, sodium ion specificSodium channel protein type 8 subunit alpha
go.drugbank.com/bio_entities/BE0002084TargetHumansPore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass … Contributes to neuronal excitability by regulating action potential threshold and propagation (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed
Polypeptides: Sodium channel protein type 8 subunit alphaSynonyms: Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6Sodium/potassium-transporting ATPase subunit alpha-4
go.drugbank.com/bio_entities/BE0005031TransporterHumansPlays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (By similarity) … Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (PubMed:16861705).
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-4Synonyms: Sodium pump subunit alpha-4