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Tiapride Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126581Drug actionTiapride is a selective D2 and D3 dopamine receptor blocker indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitati...
Enzymes: Sodium-dependent dopamine transporterChlorprothixene Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126587Drug actionChlorprothixene is a thioxanthene antipsychotic. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the ...
Enzymes: Sodium-dependent serotonin transporterTiapride Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126590Drug actionTiapride is a selective D2 and D3 dopamine receptor blocker indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitati...
Enzymes: Sodium-dependent serotonin transporterProchlorperazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126604Drug actionProchlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Dopamine-antagonizing medications such as prochlorperazine are thoug...
Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Prochlorperazine · Dopamine · Levodopa +2 moreEnzymes: Sodium-dependent dopamine transporterTriflupromazine - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126610Drug actionTriflupromazine is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can a...
Enzymes: Sodium-dependent dopamine transporterBrexpiprazole Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126698Drug actionAlthough the exact mechanism of action of brexpiprazole in psychiatric disorders has not been fully elucidated, the efficacy of brexpiprazole may be attributed to combined partial agonist activity at 5-HT1A and dopamine D2 receptors, and...
Enzymes: Sodium-dependent dopamine transporterOndansetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126768Drug actionOndansetron acts both centrally and peripherally to prevent and treat nausea and vomiting. Central effects are mediated by the antagonism of 5HT-3 serotonin receptors in the area postrema. The area postrema, located on the fourth ventric...
Enzymes: Sodium-dependent serotonin transporterDolasetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126782Drug actionDolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The a...
Enzymes: Sodium-dependent serotonin transporterPipotiazine Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126800Drug actionPipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic...
Enzymes: Sodium-dependent serotonin transporterOlanzapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126804Drug actionOlanzapine is an atypical (second-generation) antipsychotic that exerts its action primarily on dopamine and serotonin receptors. It works on dopamine D2 receptors in the mesolimbic pathway as an antagonist, blocking dopamine from potent...
Enzymes: Sodium-dependent serotonin transporter