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Dextrose, unspecified form
go.drugbank.com/drugs/DB09341ApprovedInvestigationalVet approvedIt is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). … It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation.
Products: Monoject Insulin Reaction Gel 40%Glimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigationalthought to exert extra-pancreatic effects, such as increasing the insulin-mediated peripheral glucose uptake. … Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes to lower blood glucose levels.
Categories: Insulin SecretagoguesLeucyl-cystinyl aminopeptidase
go.drugbank.com/bio_entities/BE0010031EnzymeHumansRelease of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy...
Synonyms: Insulin-responsive aminopeptidase, Insulin-regulated membrane aminopeptidaseSolute carrier family 2, facilitated glucose transporter member 4
go.drugbank.com/bio_entities/BE0000893TransporterTargetHumansResponse to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. … Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation.
Synonyms: Glucose transporter type 4, insulin-responsiveTeplizumab
go.drugbank.com/drugs/DB06606ApprovedInvestigationalexogenous insulin. … Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of type 1 diabetes (T1D).
Synonyms: Humanized OKT3Categories: Antibodies, Monoclonal, HumanizedPramlintide
go.drugbank.com/drugs/DB01278ApprovedInvestigationalIt is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
Lixisenatide
go.drugbank.com/drugs/DB09265ApprovedInvestigationalLixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA...
Categories: insulin glargine and lixisenatideCation-independent mannose-6-phosphate receptor
go.drugbank.com/bio_entities/BE0003623TargetTransporterHumansMediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phos...
Synonyms: Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptorLiraglutide
go.drugbank.com/drugs/DB06655ApprovedInvestigationalVictoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist. … [Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34.
Categories: insulin degludec and liraglutideExenatide
go.drugbank.com/drugs/DB01276ApprovedInvestigationalIt activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control[L42690].