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Displaying results 711 - 720 of 10000 in total
  1. Target

    ALK tyrosine kinase receptor

    go.drugbank.com/bio_entities/BE0000359
    TargetHumans

    Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation … MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction

    Polypeptides: ALK tyrosine kinase receptor
  2. Target

    Cholecystokinin receptor type A

    go.drugbank.com/bio_entities/BE0000402
    TargetHumans

    Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. … This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: Cholecystokinin receptor type ASynonyms: CCK-A receptor, Cholecystokinin-1 receptor
  3. Target

    Interferon gamma receptor 2

    go.drugbank.com/bio_entities/BE0000467
    TargetHumans

    Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114) … Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:7673114, PubMed:8124716).

    Polypeptides: Interferon gamma receptor 2Synonyms: IFN-gamma receptor 2, Interferon gamma receptor beta-chain
  4. Target

    Alpha-1A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000501
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1A adrenergic receptorSynonyms: Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c
  5. Target

    Kappa-type opioid receptor

    go.drugbank.com/bio_entities/BE0000632
    TargetHumans

    G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. … Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A.

    Polypeptides: Kappa-type opioid receptorFunction: dynorphin receptor activity
  6. Target

    Activin receptor type-1B

    go.drugbank.com/bio_entities/BE0000665
    TargetHumans

    Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). … Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B.

    Polypeptides: Activin receptor type-1BSynonyms: Activin receptor type IB, Activin receptor-like kinase 4
  7. Target

    Alpha-1D adrenergic receptor

    go.drugbank.com/bio_entities/BE0000715
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1D adrenergic receptorSynonyms: Alpha-1A adrenergic receptor, Alpha-adrenergic receptor 1a
  8. Target

    Metabotropic glutamate receptor 2

    go.drugbank.com/bio_entities/BE0000974
    TargetHumans

    Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794).

    Polypeptides: Metabotropic glutamate receptor 2
  9. Target

    Insulin receptor substrate 1

    go.drugbank.com/bio_entities/BE0000977
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045 … Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the

    Polypeptides: Insulin receptor substrate 1Function: insulin receptor binding
  10. Target

    Toll-like receptor 9

    go.drugbank.com/bio_entities/BE0001171
    TargetHumans

    Key component of innate and adaptive immunity (PubMed:14716310). TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms (PubMed:14716310). TLR9 is a ...

    Polypeptides: Toll-like receptor 9Function: interleukin-1 receptor binding