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Displaying results 731 - 740 of 10000 in total
  1. Target

    Filamin-A

    go.drugbank.com/bio_entities/BE0009099
    TargetHumans

    Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. … Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs.

    Polypeptides: Filamin-ASynonyms: FLN-A
  2. Target

    Toxin A

    go.drugbank.com/bio_entities/BE0010938
    TargetPeptoclostridium difficile

    Toxin A Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis … Once entered into host cells, acidification in the endosome promotes the membrane insertion of the translocation region and formation of a pore, leading to translocation of the GT44 and peptidase C80 domains

    Polypeptides: Toxin A
  3. Drug

    Interferon alfa-2a

    go.drugbank.com/drugs/DB00034
    ApprovedInvestigationalWithdrawn

    Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. … It is used extensively as an antiviral or antineoplastic agent. An oral form is being developed by Amarillo Biosciences.

    Synonyms: Interferon Alfa 2A, Interferon alfa-2aInternational brands: Roferon A
  4. Indication

    Hepatitis A

    go.drugbank.com/conditions/DBCOND0000799
    Drugs: Hepatitis A Vaccine · Hepatitis B Vaccine (Recombinant) · Human immunoglobulin G
    Synonyms: Hep A, Hepatitis A
  5. Indication

    Immunoglobulin A Nephropathy

    go.drugbank.com/conditions/DBCOND0063172
    Drugs: Atrasentan
    Synonyms: Immunoglobulin A Nephropathy
  6. Indication

    Deficiency, Vitamin A

    go.drugbank.com/conditions/DBCOND0085163
    Drugs: Ascorbic acid · Beta carotene · Cholecalciferol · Cod liver oil · Ergocalciferol · Vitamin A +1 more
    Synonyms: Hypovitaminosis A, Deficiency, Vitamin A
  7. Drug

    Reviparin

    go.drugbank.com/drugs/DB09259
    Approved

    Reviparin is a low molecular weight heparin which seems to have a better safety profile than unfractionated heparin. … Reviparin has a molecular weight of 3.9 kDa.[A32021] It was developed by Abbott laboratories and in 2009, reviparin presented an orphan drug designation by the FDA.[L1469]

    Products: CLIVARIN 5726 IE A XA/ML, CLIVARODI 17178 A XA/ML
  8. Drug

    Hydrocortisone succinate

    go.drugbank.com/drugs/DB14545
    ApprovedInvestigational

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InducersProducts: A-hydrocort, A-hydrocort Inj 250mg/2ml
  9. Drug

    Interferon alfa

    go.drugbank.com/drugs/DB05258
    ApprovedInvestigationalWithdrawn

    Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography. … Multiferon consists of the 6 major subtypes are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. Of these, IFN-α2 and IFN-α14 are glycosylated.

    Categories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: IFN-α
  10. Drug

    Diphenhydramine

    go.drugbank.com/drugs/DB01075
    ApprovedInvestigational

    As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties. … Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies,

    Synonyms: N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine, 2-(benzhydryloxy)-N,N-dimethylethylamineInternational brands: Dormarex 2