Search

Displaying results 731 - 740 of 1809 in total
  1. Drug

    Mifamurtide

    go.drugbank.com/drugs/DB13615
    ApprovedInvestigational

    Mifamurtide is an immunomodulator with antitumor activity via activation of macrophages and monocytes. … In a large, randomized, open-label, multicenter, phase III trial, the treatment of mifamurtide in conjunction with three- or four-drug combination chemotherapy (doxorubicin, cisplatin, and high-dose methotrexate

  2. Target

    Peroxisome proliferator-activated receptor alpha

    go.drugbank.com/bio_entities/BE0000071
    TargetHumans

    Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids.

    Polypeptides: Peroxisome proliferator-activated receptor alphaSynonyms: Nuclear receptor subfamily 1 group C member 1
  3. Target

    Glutamate receptor ionotropic, NMDA 1

    go.drugbank.com/bio_entities/BE0000365
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26...

    Polypeptides: Glutamate receptor ionotropic, NMDA 1Synonyms: Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1
  4. Target

    Glutamate receptor ionotropic, NMDA 2D

    go.drugbank.com/bio_entities/BE0000396
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:27616483, PubMed:28...

    Polypeptides: Glutamate receptor ionotropic, NMDA 2DSynonyms: N-methyl D-aspartate receptor subtype 2D, Glutamate [NMDA] receptor subunit epsilon-4
  5. Target

    Glycine receptor subunit alpha-3

    go.drugbank.com/bio_entities/BE0000414
    TargetHumans

    Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:26416729, PubMed:9677400). Channel characteristics depend on the subunit composition; heteropentameric channels display f...

    Polypeptides: Glycine receptor subunit alpha-3
  6. Target

    Activin receptor type-1-like

    go.drugbank.com/bio_entities/BE0000459
    TargetHumans

    Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

    Polypeptides: Activin receptor type-1-likeSynonyms: Activin receptor-like kinase 1, TGF-B superfamily receptor type I
  7. Target

    Interleukin-1 receptor type 1

    go.drugbank.com/bio_entities/BE0000565
    TargetHumans

    Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. … Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560).

    Polypeptides: Interleukin-1 receptor type 1Synonyms: Interleukin-1 receptor alpha, Interleukin-1 receptor type I
  8. Target

    Growth hormone-releasing hormone receptor

    go.drugbank.com/bio_entities/BE0000625
    TargetHumans

    Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion

    Polypeptides: Growth hormone-releasing hormone receptorSynonyms: GRF receptor, GHRH receptor
  9. Target

    Glutamate receptor ionotropic, NMDA 3A

    go.drugbank.com/bio_entities/BE0000641
    TargetHumans

    Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:38598639). … Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity).

    Polypeptides: Glutamate receptor ionotropic, NMDA 3ASynonyms: N-methyl-D-aspartate receptor subtype 3A
  10. Target

    Interleukin-2 receptor subunit beta

    go.drugbank.com/bio_entities/BE0000651
    TargetHumans

    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

    Polypeptides: Interleukin-2 receptor subunit betaSynonyms: IL-2 receptor subunit beta, High affinity IL-2 receptor subunit beta