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Displaying results 751 - 760 of 10000 in total
  1. Drug

    Obecabtagene autoleucel

    go.drugbank.com/drugs/DB17362
    ApprovedInvestigational

    [A265040,A265045] It works by targeting B-cell-specific CD19 surface markers present on malignant B cells. … Obecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19.

    Categories: Genetically-modified Autologous T Cells, CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesSynonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OBTAINED BY APHERESIS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING
  2. Target

    Flavohemoprotein

    go.drugbank.com/bio_entities/BE0001704
    TargetCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

    Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various

    Synonyms: NO oxygenase
  3. Indication

    Myeloproliferative Disorders

    go.drugbank.com/conditions/DBCOND0029888
    Drugs: Imatinib
    Synonyms: Myeloproliferative disease, no ICD-O subtype, Chronic myeloproliferative disease, no ICD-O subtype
  4. Indication

    Trigeminal Neuralgia (TN)

    go.drugbank.com/conditions/DBCOND0081925
    Drugs: Botulinum toxin type A · Methotrimeprazine · Pyridoxine
    Synonyms: Trigeminal neuralgia [no drugs here] (disorder)
  5. Indication

    Osteogenesis Imperfecta (OI)

    go.drugbank.com/conditions/DBCOND0113457
    Drugs: Alendronic acid · Neridronic Acid
    Synonyms: Osteogenesis Imperfecta, Type I, Osteogenesis imperfecta type I
  6. Target

    Flavohemoprotein

    go.drugbank.com/bio_entities/BE0002917
    TargetEscherichia coli (strain K12)

    Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various

    Synonyms: NO oxygenase
  7. Indication

    Peripheral T-Cell Lymphoma (PTCL)

    go.drugbank.com/conditions/DBCOND0079798
    Drugs: Brentuximab vedotin
    Synonyms: Peripheral T-cell lymphoma, no ICD-O subtype, Peripheral T-cell lymphoma, no International Classification of Diseases for Oncology subtype
  8. Drug

    Peracetic acid

    go.drugbank.com/drugs/DB14556
    Investigational

    A liquid that functions as a strong oxidizing agent. It has an acrid odor and is used as a disinfectant.

    Categories: Compounds used in a research, industrial, or household settingProducts: Peraflu D, Pu Us Pure
  9. Drug

    Lovastatin

    go.drugbank.com/drugs/DB00227
    ApprovedInvestigational

    [A174580,A181409,A181535,A181538,A1793] Potency is thought to correlate to tissue permeability as the more lipophilic statins such as lovastatin are thought to enter endothelial cells by passive diffusion … were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while lovastatin has been found to have an average decrease in LDL-C of 25-40%.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsSynonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
  10. Drug

    Magnesium lactate

    go.drugbank.com/drugs/DB14515
    InvestigationalNutraceutical

    Products: Magnesium Lactate Cap 70mg