Osteogenesis Imperfecta (OI) (DBCOND0113457)

Identifiers

Synonyms
Brittle Bone Disease / Osteogenesis Imperfecta / Osteogenesis imperfecta (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Alendronic acid
A bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis.
Neridronic Acid
A bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis.
Oxidronic acid
Oxidronic acid is a diagnostic skeletal imaging agent used to demonstrate areas of altered osteogenesis in adult and pediatric patients.
No drug targets
Technetium Tc-99m oxidronate
Technetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is...
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03638128
Open-label Extension of Study 20130173 of Denosumab in Children and Young Adults With Osteogenesis Imperfectatreatment3terminated
NCT02868294
Preventive Fixation of Lower Limbs in Osteogenesis Imperfecta (Brittle Bone Disease) With the Highlight of the Fassier-DuvalNo drug interventionstreatmentNot Availableunknown_status
NCT00001594
Evaluation and Intervention for the Effects of Osteogenesis ImperfectaNo drug interventionsNot AvailableNot Availablecompleted
NCT03064074
Safety of Fresolimumab in the Treatment of Osteogenesis Imperfectatreatment1completed
NCT06636071
Setrusumab in Pediatric Japanese Subjects with Osteogenesis Imperfectatreatment3not_yet_recruiting
NCT05612139
Post-market Observational Study on JTIN Telescopic Nail in Osteogenesis Imperfecta Pediatric PatientsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT05972551
Study to Evaluate Efficacy and Safety of Romosozumab Compared with Bisphosphonates in Children and Adolescents with Osteogenesis Imperfectatreatment3recruiting
NCT06397443
Ready to Sail: Evaluating Sailing's Feasibility as ErgotherapyNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT03072303
Pregnancy in Osteogenesis Imperfecta (OI) RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT04815564
Clear Aligners for the Treatment of Dental Malocclusion in OINo drug interventionssupportive_careNot Availablerecruiting
NCT05768854
Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfectatreatment3active_not_recruiting
NCT04152551
Effects of Bisphosphonates on OI-Related Hearing Lossprevention4recruiting
NCT02934451
Dental Malocclusion and Craniofacial Development in OINo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02352753
Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OItreatment3terminated
NCT01799798
Translational Therapy in Patients With Osteogenesis Imperfecta - A Pilot Trial on Treatment With the Rankl-Antibody Denosumabtreatment2completed
NCT05312697
Long-term Extension Study of Setrusumab in Adults With Type I, III, or IV Osteogenesis Imperfectatreatment2terminated
NCT04844697
Resilience and Coping in a Rare Skeletal Disease Population to Face Coronavirus (COVID-19) Outbreak Distress: a Longitudinal StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT06065111
Study of Osteogenesis Imperfecta TendonNo drug interventionsNot AvailableNot Availablerecruiting
NCT03841188
Nutritional Interventional in Pediatric Patients With Osteogenesis ImperfectaNo drug interventionssupportive_careNot Availablecompleted
NCT04119388
Evaluation of the Benefits of Adaptive Physical Activity in Children and Adolescents With Osteogenesis ImperfectaNo drug interventionspreventionNot Availablecompleted
NCT05317637
Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708No drug interventionsNot AvailableNot Availablerecruiting
NCT03735537
Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acidtreatment4unknown_status
NCT06193642
Increasing Knowledge on Osteogenesis Imperfecta by Collecting Epidemiological DataNo drug interventionsotherNot Availableactive_not_recruiting
NCT05321199
Tranexamic Acid During Telescoping Nail Application In Osteogenesis ImperfectascreeningNot Availablecompleted
NCT05258019
Site Preservation After Tooth ExtractionNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06010134
Osteogenesis Imperfecta and BalanceNo drug interventionstreatmentNot Availablerecruiting
NCT04231916
High Resolution Thermal Imaging to Identify Vertebral Fractures in Children and Young People With Osteogenesis ImperfectaNo drug interventionsdiagnosticNot Availablecompleted
NCT02793063
Osteogenesis Imperfecta (OI) Quality of Life Survey Pilot Project 2No drug interventionsNot AvailableNot Availablecompleted
NCT05878548
Management of Combined Fracture Neck of Femur and Femoral Deformity in Osteogenesis Imperfecta PatientNo drug interventionstreatmentNot Availablerecruiting
NCT00705120
Treatment of Severe Osteogenesis Imperfecta by Allogeneic Bone Marrow Transplantationtreatment1completed
NCT01713231
Effect of High-Dose Vitamin D on Bone Density in Osteogenesis ImperfectaNo drug interventionssupportive_care4completed
NCT02303873
Efficacy and Safety of Alendronate in Chinese Children or Adolescents With Osteogenesis Imperfectatreatment4completed
NCT01679080
The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfectatreatment2terminated
NCT05927389
Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Osteogenesis ImperfectaNo drug interventionspreventionNot Availablerecruiting
NCT04694144
Results of Telescoping Nail In OI; a Case SeriesNo drug interventionsNot AvailableNot Availableunknown_status
NCT03557567
NGS Strategy Effectiveness in Molecular DiagnosisNo drug interventionsNot AvailableNot Availablecompleted
NCT05559801
Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI)treatment1 / 2not_yet_recruiting
NCT04169568
Osteogenesis Imperfecta Blood Pressure StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05231668
Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI)No drug interventionstreatment1recruiting
NCT03029312
Whole Body Vibration Training in Children With Osteogenesis Imperfecta and Limited MobilityNo drug interventionstreatmentNot Availablecompleted
NCT04282408
Experimental Evaluation of Back Braces for the Treatment of Spinal Deformity Produced With 3D Printing TechnologyNo drug interventionsdevice_feasibilityNot Availablecompleted
NCT03575221
Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and Genotype Phenotype CorrelationNo drug interventionsNot AvailableNot Availablecompleted
NCT00063479
Bisphosphonate Treatment of Osteogenesis Imperfectatreatment2completed
NCT02531087
Urinary Biomarkers of OI PathobiologyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04009733
Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI StudyNo drug interventionsotherNot Availablecompleted
NCT04545554
Study to Evaluate Romosozumab in Children and Adolescents With Osteogenesis Imperfectatreatment1completed
NCT00001305
Growth Hormone Therapy in Osteogenesis Imperfectatreatment3completed
NCT00106028
Safety and Efficacy of Risedronate in the Treatment of Osteogenesis Imperfecta in Childrentreatment3completed
NCT05125809
Study to Assess Dose, Efficacy and Safety of Setrusumab in Participants With Osteogenesis Imperfectatreatment2 / 3active_not_recruiting
NCT02172885
Mesenchymal Stem Cell Based Therapy for the Treatment of Osteogenesis ImperfectaNo drug interventionstreatment1completed
NCT04623606
Boost to Brittle Bones - Stem Cell Transplantation for Treatment of Brittle BonesNo drug interventionstreatment1 / 2unknown_status
NCT06555536
e-Health Care Method for Patients With Osteogenesis Imperfecta (Tele OI)No drug interventionssupportive_careNot Availablecompleted
NCT06086613
A First-in-Human Study Evaluating AGA2115 in Adult Healthy Volunteerstreatment1recruiting
NCT00187018
Marrow Mesenchymal Cell Therapy for Osteogenesis Imperfecta: A Pilot StudyNo drug interventionstreatmentNot Availablecompleted
NCT00131118
Zoledronic Acid in Children (1 -17 Years) With Severe Osteogenesis Imperfectatreatment2completed
NCT00159419
Bisphosphonate Therapy for Osteogenesis Imperfectatreatment4completed
NCT00982124
An Efficacy and Safety Trial of Intravenous Zoledronic Acid in Infants Less Than One Year of Age, With Severe Osteogenesis Imperfectasupportive_care3completed
NCT03216486
An Exploratory Study of BPS804 Treatment in Adult Patients With Type I, III or IV Osteogenesis Imperfectatreatment2withdrawn
NCT02432625
BBD Longitudinal Study of Osteogenesis ImperfectaNo drug interventionsNot AvailableNot Availablerecruiting
NCT00076830
Evaluation and Treatment of Patients With Connective Tissue DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04115774
Registry of Osteogenesis ImperfectaNo drug interventionsNot AvailableNot Availablerecruiting
NCT03706482
Boost Brittle Bones Before BirthNo drug interventionstreatment1 / 2active_not_recruiting
NCT03208582
Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta?basic_science2completed
NCT05419960
Audio-vestibular Evaluation of Children and Young Adults With Osteogenesis ImperfectaNo drug interventionsNot AvailableNot Availablerecruiting
NCT02814591
Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman SpectroscopyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01417091
Safety, Pharmacokinetics and Pharmacodynamics of BPS804 in Osteogenesis Imperfectatreatment2completed
NCT02542540
Effects of a Physical Rehabilitation Program Using the Nintendo Wii on Children With Osteogenesis Imperfecta (OI)No drug interventionsNot AvailableNot Availableterminated
NCT00005901
Pamidronate to Treat Osteogenesis Imperfecta in Childrentreatment3completed
NCT00131469
Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfectatreatment4completed
NCT00655681
Prevention of Post Operative Bone Loss in ChildrenpreventionNot Availablecompleted