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Displaying results 761 - 770 of 10000 in total
  1. Drug

    Nemvaleukin alfa

    go.drugbank.com/drugs/DB18187
    Investigational

    Synonyms: Fusion protein comprised of a circularly-permuted interleukin-2 (IL-2) with the extracellular domain of IL-2 receptor alpha, 2 receptor α-chain (human)
  2. Drug

    Penicillamine

    go.drugbank.com/drugs/DB00859
    ApprovedInvestigational

    Penicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). … It is an α-amino acid metabolite of penicillin, although it has no antibiotic properties.

    Categories: Compounds used in a research, industrial, or household settingSynonyms: 3-mercapto-D-valine, (S)-2-amino-3-mercapto-3-methylbutanoic acid
  3. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0000366
    TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A
  4. Target

    Leukotriene A-4 hydrolase

    go.drugbank.com/bio_entities/BE0001680
    TargetHumans

    Can utilize LTA5 less effectively as a substrate than LTA4, and produce LTB5 (PubMed:2996528). … addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a

    Polypeptides: Leukotriene A-4 hydrolaseSynonyms: Leukotriene A(4) hydrolase
  5. Target

    Acetyl-coenzyme A synthetase

    go.drugbank.com/bio_entities/BE0001916
    TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

    Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.

    Polypeptides: Acetyl-coenzyme A synthetase
  6. Target

    Nucleoside diphosphate kinase A

    go.drugbank.com/bio_entities/BE0003106
    TargetEnzymeHumans

    Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore … May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing (

    Polypeptides: Nucleoside diphosphate kinase ASynonyms: NDPK A, NDP kinase A
  7. Target

    Stringent starvation protein A

    go.drugbank.com/bio_entities/BE0003260
    TargetYersinia pestis

    Polypeptides: Stringent starvation protein ASynonyms: Putative stringent starvation protein A, Regulator of transcription stringent starvation protein A
  8. Target

    Poly(A) polymerase alpha

    go.drugbank.com/bio_entities/BE0004515
    TargetHumans

    May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus … Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites.

    Polypeptides: Poly(A) polymerase alpha
  9. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008382
    TargetEscherichia coli (strain K12)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed:12051842, PubMed:18642932,

    Polypeptides: DNA gyrase subunit A
  10. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008385
    TargetStaphylococcus aureus

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A