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Displaying results 781 - 790 of 2256 in total
  1. Target

    Atypical chemokine receptor 1

    go.drugbank.com/bio_entities/BE0015068
    TargetHumans

    Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead … Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.

    Polypeptides: Atypical chemokine receptor 1Synonyms: Plasmodium vivax receptor, Duffy antigen/chemokine receptor
  2. Target

    Interferon lambda receptor 1

    go.drugbank.com/bio_entities/BE0016547
    TargetHumans

    The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. … Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense.

    Polypeptides: Interferon lambda receptor 1Synonyms: IFN-lambda receptor 1, IL-28 receptor subunit alpha
  3. Target

    Interleukin-17 receptor D

    go.drugbank.com/bio_entities/BE0017358
    TargetHumans

    Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12807873, PubMed:12958313). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK wi...

    Polypeptides: Interleukin-17 receptor DSynonyms: IL-17 receptor D, Interleukin-17 receptor-like protein
  4. Target

    Lysophosphatidic acid receptor 1

    go.drugbank.com/bio_entities/BE0017535
    TargetHumans

    Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). … Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.

    Polypeptides: Lysophosphatidic acid receptor 1Synonyms: LPA receptor 1, Lysophosphatidic acid receptor Edg-2
  5. Target

    Interleukin-17 receptor A

    go.drugbank.com/bio_entities/BE0018249
    TargetHumans

    Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). … Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848)

    Polypeptides: Interleukin-17 receptor ASynonyms: IL-17 receptor A
  6. Target

    Interleukin-17 receptor B

    go.drugbank.com/bio_entities/BE0020027
    TargetHumans

    Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells

    Polypeptides: Interleukin-17 receptor BSynonyms: IL-17 receptor B, IL-17B receptor
  7. Target

    Insulin receptor substrate 2

    go.drugbank.com/bio_entities/BE0021286
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670 … Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of

    Polypeptides: Insulin receptor substrate 2
  8. Drug

    Ethinylestradiol

    go.drugbank.com/drugs/DB00977
    ApprovedInvestigational

    Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering. It was developed in an effort to create an estrogen with greater oral bioavailability. These properties were achieved by the substitu...

    Mixtures: PIL KB HARMONIS, PIL KB I KOMBINASIProducts: NAVEEN
  9. Drug

    Teglarinad chloride

    go.drugbank.com/drugs/DB05217
    Investigational

    Although the exact mechanism of action has yet to be fully elucidated, GMX1778 appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.

  10. Drug

    Telmisartan

    go.drugbank.com/drugs/DB00966
    ApprovedInvestigational

    [A1489,A1490] Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.[A1492] … Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

    Categories: Angiotensin 2 Receptor Blocker, Angiotensin II receptor antagonists