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Displaying results 71 - 80 of 509 in total
  1. Target

    Alpha-ketoglutarate-dependent sulfate ester dioxygenase

    go.drugbank.com/bio_entities/BE0003185
    TargetPseudomonas putida

    It can catalyze the cleavage of medium-chain alkyl sulfate esters such as butylsulfate, pentylsulfate, hexylsulfate, heptylsulfate, octylsulfate, nonylsulfate, decylsulfate and sodium dodecyl sulfate ( … Catalyzes the oxygenolytic cleavage of 2-ethylhexyl sulfate (2-EHS) in the presence of alpha-ketoglutarate to yield 2-ethyl-hexanal and succinate, the decarboxylated form of alpha-ketoglutarate.

    Polypeptides: Alpha-ketoglutarate-dependent sulfate ester dioxygenaseSynonyms: Type II alkyl sulfatase
  2. Target

    Activated CDC42 kinase 1

    go.drugbank.com/bio_entities/BE0000772
    TargetHumans

    May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. … Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation.

    Polypeptides: Activated CDC42 kinase 1
  3. Target

    Peroxisome proliferator-activated receptors

    go.drugbank.com/bio_entities/BE0010120
    TargetHumans and other mammals

    Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). … Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.

    Polypeptides: Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor deltaSynonyms: Peroxisome proliferator-activated receptor beta
  4. Target

    Proteinase-activated receptor 1

    go.drugbank.com/bio_entities/BE0000928
    TargetHumans

    Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (PubMed:30568593, … May play a role in platelets activation and in vascular development (PubMed:10079109).

    Polypeptides: Proteinase-activated receptor 1
  5. Target

    Bile salt-activated lipase

    go.drugbank.com/bio_entities/BE0004523
    TargetEnzymeHumans

    Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) ( … Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed:10220579, PubMed:27509211, PubMed:27650499,

    Polypeptides: Bile salt-activated lipase
  6. Target

    Calcium-activated potassium channel

    go.drugbank.com/bio_entities/BE0004906
    TargetHumans

    Possibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic … It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane.

    Polypeptides: Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta-1Synonyms: Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel, subfamily M subunit alpha-1
  7. Target

    Sodium-dependent proline transporter

    go.drugbank.com/bio_entities/BE0000723
    TargetHumans

    Brain specific sodium (and chloride)-dependent proline transporter (PubMed:7651355). … Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable)

    Polypeptides: Sodium-dependent proline transporter
  8. Target

    Sodium/myo-inositol cotransporter

    go.drugbank.com/bio_entities/BE0009368
    TransporterHumans

    Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability … Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity).

    Polypeptides: Sodium/myo-inositol cotransporterSynonyms: Sodium/myo-inositol transporter 1
  9. Target

    Sodium-dependent noradrenaline transporter

    go.drugbank.com/bio_entities/BE0000486
    TargetTransporterHumans

    Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:11093780, PubMed:8125921, PubMed:39395208, PubMed:39048818) … Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:2008212, PubMed

    Polypeptides: Sodium-dependent noradrenaline transporter
  10. Target

    Sodium-dependent dopamine transporter

    go.drugbank.com/bio_entities/BE0000647
    TargetTransporterHumans

    Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). … Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:39112701, PubMed:39112703, PubMed:39112705, PubMed

    Polypeptides: Sodium-dependent dopamine transporter