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ADP-ribosylation factor 4
go.drugbank.com/bio_entities/BE0003277TargetHumansPart of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879 … Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Polypeptides: ADP-ribosylation factor 4Function: epidermal growth factor receptor bindingGrowth/differentiation factor 8
go.drugbank.com/bio_entities/BE0003435TargetHumansActs specifically as a negative regulator of skeletal muscle growth
Polypeptides: Growth/differentiation factor 8Cobalamin binding intrinsic factor
go.drugbank.com/bio_entities/BE0004690TransporterCarrierHumansPromotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis
Polypeptides: Cobalamin binding intrinsic factorSynonyms: Intrinsic factor, Gastric intrinsic factorFactor VII-activating protease
go.drugbank.com/bio_entities/BE0004940TargetHumansActivates coagulation factor VII (Probable). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560) … Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does
Polypeptides: Factor VII-activating proteaseSynonyms: Hepatocyte growth factor activator-like proteinCOUP transcription factor 1
go.drugbank.com/bio_entities/BE0008953TargetHumansCoup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. … Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG
Polypeptides: COUP transcription factor 1Synonyms: COUP transcription factor IHepatoma-derived growth factor
go.drugbank.com/bio_entities/BE0008975TargetHumansActs as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618)
Polypeptides: Hepatoma-derived growth factorPigment epithelium-derived factor
go.drugbank.com/bio_entities/BE0009068TargetHumansNeurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins...
Polypeptides: Pigment epithelium-derived factorElongation factor 1-alpha
go.drugbank.com/bio_entities/BE0009166TargetPlasmodium falciparum (isolate K1 / Thailand)This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Polypeptides: Elongation factor 1-alphaTranscription factor PU.1
go.drugbank.com/bio_entities/BE0010802TargetHumansPioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. … Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon
Polypeptides: Transcription factor PU.1Oligodendrocyte transcription factor 2
go.drugbank.com/bio_entities/BE0014194TargetHumansAntagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development … Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis.
Polypeptides: Oligodendrocyte transcription factor 2Function: DNA-binding transcription factor activity, RNA polymerase II-specific