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Nortriptyline Action Pathway
smpdb.ca/view/SMP0126345Drug actionThis drug is also used off-label and it includes the treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome. … Nortriptyline exerts antidepressant functions by inhibiting the reuptake of serotonin and norepinephrine in the neurons.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreSolriamfetol Action Pathway
smpdb.ca/view/SMP0126346Drug actionThose transporters are called sodium-dependent dopamine transporter and sodium-dependent noradrenaline transporter. This makes more dopamine and noradrenaline available in the synapses of the brain. … Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI).
Desipramine Action Pathway (New)
smpdb.ca/view/SMP0126352Drug actionIt binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter of the presynaptic neurons. … It can also be used to manage chronic neuropathic pain, as a second-line agent for the management of anxiety disorders, and as a second or third-line agent in ADHD management.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreAtomoxetine Action Pathway (New)
smpdb.ca/view/SMP0126353Drug actionDue to atomoxetine's noradrenergic activity, it also has effects on the cardiovascular system such as increased blood pressure and tachycardia. … Although the underlying pathophysiology that causes ADHD remains undefined, evidence suggests that dysregulation in noradrenergic and dopaminergic pathways plays a critical role.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Atomoxetine · Sapropterin · Norepinephrine +5 moreDoxepin Norepinephrine Reuptake Inhibitor Action Pathway (New)
smpdb.ca/view/SMP0126355Drug actionDoxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. … Doxepin binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreMilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126429Drug actionMilnacipran is a serotonin and norepinephrine reuptake inhibitor (SNRI). … It is generally believed that 5HT and NE participate in the modulation of endogenous analgesic mechanisms by way of the descending inhibitory pain pathways in the brain and spinal cord.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreLevomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126430Drug actionIt is generally believed that 5HT and NE participate in the modulation of endogenous analgesic mechanisms by way of the descending inhibitory pain pathways in the brain and spinal cord. … Levomilnacipran (the more active 1S, 2R - enantiomer of milnacipran) is a serotonin and norepinephrine reuptake inhibitor (SNRI).
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreCaffeine Cardiac Contraction Action Pathway
smpdb.ca/view/SMP0126520Drug actionCaffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. … This means that much of the research is not well understood, and there is much conflicting data on caffeine.
Cocaine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126544Drug actionIt primarily acts on sensory neurons in the nasal cavity, but also inhibits dopamine, serotonin, and norepinephrine re-uptake channels. … Cocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic proceedures or during surgery in or through the nasal cavity.
Tranylcypromine Amine Oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126672Drug actionAn overdose of this drug will result in insomnia, restlessness, and anxiety. Hypotension, dizziness, weakness, and drowsiness may occur, progressing in severe cases to extreme dizziness and shock. … The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine.