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Ropinirole Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126458Drug actionRopinirole has a high affinity for and stimulates the post-synaptic dopamine receptors D2 in the central and peripheral nervous systems. … They inhibit adenylyl cyclase and calcium (Ca2+) channels and activate potassium channels leading to their physiological functions.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorTriflupromazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126491Drug actionTriflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B). … It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorTriflupromazine - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126610Drug actionTriflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B). … It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorGlycogenosis, Type IA. Von Gierke Disease
smpdb.ca/view/SMP0125796DiseaseGlycogenosis, Type IA, also called Von Gierke Disease, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder and caused by a defective glucose-6-phosphatase. … Glucose-6-phosphatase catalyzes the conversion of glucose 6-phosphate into D-glucose and conversion of D-glucose to glucose 6-phosphate.
Perphenazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126530Drug actionBinds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. … The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorChlorprothixene Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126577Drug actionChlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating … system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorZuclopenthixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126579Drug actionIt has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and alpha2-adrenergic receptors. … It mainly acts by antagonism of D1 and D2 dopamine receptors. Zuclopenthixol also has high affinity for alpha1-adrenergic and 5-HT2 receptors.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorCariprazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126662Drug actionPreclinical studies suggest that D3 receptor blockade is associated with exerting pro-cognitive and antidepressant effects and attenuating negative symptoms in schizophrenia. … Cariprazine is indicated for the treatment of schizophrenia in adults to manage both positive and negative symptoms.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorThiothixene Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126580Drug actionThiothixene acts as an antagonist (blocking agent) on different post-sysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive … symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorPipotiazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126810Drug actionPipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive … symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptor