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Displaying results 791 - 800 of 10000 in total
  1. Indication

    Prevention of subtype A viruses contained in the 2015 formula Influenza A Virus Infection

    go.drugbank.com/conditions/DBCOND0112773
    Drugs: Influenza A virus A/Slovenia/2903/2015 (H1N1) live (attenuated) antigen
    Synonyms: Prevention of subtype A viruses contained in the 2015 formula Influenza A Virus Infection
  2. Target

    Ephrin type-A receptor 7

    go.drugbank.com/bio_entities/BE0004140
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion.

    Polypeptides: Ephrin type-A receptor 7
  3. Target

    Ephrin type-A receptor 3

    go.drugbank.com/bio_entities/BE0009437
    TargetHumans

    Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5 (By similarity). … Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:12794130). Involved in the retinotectal mapping of neurons.

    Polypeptides: Ephrin type-A receptor 3Synonyms: Tyrosine-protein kinase receptor ETK1
  4. Target

    Ephrin type-A receptor 6

    go.drugbank.com/bio_entities/BE0009439
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)

    Polypeptides: Ephrin type-A receptor 6
  5. Target

    Ephrin type-A receptor 2

    go.drugbank.com/bio_entities/BE0000841
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis

    Polypeptides: Ephrin type-A receptor 2Synonyms: Tyrosine-protein kinase receptor ECK
  6. Target

    Ephrin type-A receptor 1

    go.drugbank.com/bio_entities/BE0009436
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis

    Polypeptides: Ephrin type-A receptor 1Synonyms: Tyrosine-protein kinase receptor EPH, Erythropoietin-producing hepatoma receptor
  7. Target

    Ephrin type-A receptor 8

    go.drugbank.com/bio_entities/BE0009440
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … During development of the nervous system also plays a role in axon guidance.

    Polypeptides: Ephrin type-A receptor 8Synonyms: Tyrosine-protein kinase receptor EEK
  8. Drug

    Interferon alfa

    go.drugbank.com/drugs/DB05258
    ApprovedInvestigationalWithdrawn

    Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography. … Multiferon consists of the 6 major subtypes are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. Of these, IFN-α2 and IFN-α14 are glycosylated.

    Categories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: IFN-α
  9. Target

    Ephrin type-A receptor 5

    go.drugbank.com/bio_entities/BE0005587
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5.

    Polypeptides: Ephrin type-A receptor 5
  10. Target

    Ephrin type-A receptor 4

    go.drugbank.com/bio_entities/BE0009438
    TargetHumans

    In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. … In addition to its role in axonal guidance plays a role in synaptic plasticity.

    Polypeptides: Ephrin type-A receptor 4Synonyms: Tyrosine-protein kinase receptor SEK