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Displaying results 8091 - 8100 of 10000 in total
  1. Target

    Carminomycin 4-O-methyltransferase DnrK

    go.drugbank.com/bio_entities/BE0001712
    TargetStreptomyces peucetius

    In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O-position of carminomycin to form daunorubicin. … In vitro, it also methylates the anthracyclines rhodomycin D (10-carbomethoxy-13-deoxycarminomycin) and 13-deoxy-carminomycin at the 4-hydroxyl position.

    Polypeptides: Carminomycin 4-O-methyltransferase DnrKSynonyms: Anthracycline 4-O-methyltransferase
  2. Target

    Excitatory amino acid transporter 4

    go.drugbank.com/bio_entities/BE0002270
    TargetHumans

    Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:26690923, PubMed:7791878). Functions as a symporter that transports one amino acid molecule toget...

    Polypeptides: Excitatory amino acid transporter 4
  3. Target

    Interleukin-4 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0002420
    TargetHumans

    Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation.

    Polypeptides: Interleukin-4 receptor subunit alphaSynonyms: IL-4 receptor subunit alpha
  4. Target

    Ephrin type-B receptor 4

    go.drugbank.com/bio_entities/BE0002453
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously to transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the ...

    Polypeptides: Ephrin type-B receptor 4
  5. Target

    DTDP-4-dehydrorhamnose 3,5-epimerase

    go.drugbank.com/bio_entities/BE0002995
    TargetStreptococcus suis

    Polypeptides: dTDP-4-dehydrorhamnose 3,5-epimeraseFunction: dTDP-4-dehydrorhamnose 3,5-epimerase activity
  6. Target

    Type-4 uracil-DNA glycosylase

    go.drugbank.com/bio_entities/BE0003080
    TargetThermus thermophilus

    Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G, U/A, U/C or U/T base pair as well...

    Polypeptides: Type-4 uracil-DNA glycosylaseFunction: 4 iron, 4 sulfur cluster binding
  7. Target

    Hepatocyte nuclear factor 4-gamma

    go.drugbank.com/bio_entities/BE0003179
    TargetHumans

    Transcription factor. Has a lower transcription activation potential than HNF4-alpha

    Polypeptides: Hepatocyte nuclear factor 4-gammaSynonyms: HNF-4-gamma, Nuclear receptor subfamily 2 group A member 2
  8. Target

    DNA topoisomerase 4 subunit B

    go.drugbank.com/bio_entities/BE0003294
    TargetEscherichia coli (strain K12)

    Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes (PubMed:9334322). It relaxes supercoiled DNA (PubMed:15105144, PubMed:21300644, PubMed:232946...

    Polypeptides: DNA topoisomerase 4 subunit B
  9. Target

    Free fatty acid receptor 4

    go.drugbank.com/bio_entities/BE0003399
    TargetHumans

    Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (PubMed:23809162). … Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that

    Polypeptides: Free fatty acid receptor 4Synonyms: Omega-3 fatty acid receptor 1
  10. Target

    Collagen alpha-4(IV) chain

    go.drugbank.com/bio_entities/BE0003498
    TargetHumans

    Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen

    Polypeptides: Collagen alpha-4(IV) chain