Search

Displaying results 821 - 830 of 1993 in total
  1. Target

    Retinoic acid receptor gamma

    go.drugbank.com/bio_entities/BE0000144
    TargetHumans

    Receptor for retinoic acid.

    Polypeptides: Retinoic acid receptor gammaSynonyms: Nuclear receptor subfamily 1 group B member 3
  2. Target

    Toll-like receptor 7

    go.drugbank.com/bio_entities/BE0000155
    TargetHumans

    Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612).

    Polypeptides: Toll-like receptor 7
  3. Target

    Gonadotropin-releasing hormone receptor

    go.drugbank.com/bio_entities/BE0000203
    TargetHumans

    This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling … Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH

    Polypeptides: Gonadotropin-releasing hormone receptorSynonyms: GnRH receptor
  4. Target

    Activin receptor type-1

    go.drugbank.com/bio_entities/BE0000264
    TargetHumans

    As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed:17911401). … Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation

    Polypeptides: Activin receptor type-1Synonyms: Activin receptor type I, Activin receptor-like kinase 2
  5. Target

    Alpha-2A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000289
    TargetHumans

    Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (...

    Polypeptides: Alpha-2A adrenergic receptorSynonyms: Alpha-2 adrenergic receptor subtype C10
  6. Target

    Melatonin receptor type 1B

    go.drugbank.com/bio_entities/BE0000327
    TargetHumans

    High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. … The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity

    Polypeptides: Melatonin receptor type 1BSynonyms: Mel-1B-R, Mel1b receptor
  7. Target

    ALK tyrosine kinase receptor

    go.drugbank.com/bio_entities/BE0000359
    TargetHumans

    Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation … MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction

    Polypeptides: ALK tyrosine kinase receptor
  8. Target

    Cholecystokinin receptor type A

    go.drugbank.com/bio_entities/BE0000402
    TargetHumans

    Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. … This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: Cholecystokinin receptor type ASynonyms: CCK-A receptor, Cholecystokinin-1 receptor
  9. Target

    Interferon gamma receptor 2

    go.drugbank.com/bio_entities/BE0000467
    TargetHumans

    Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114) … Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:7673114, PubMed:8124716).

    Polypeptides: Interferon gamma receptor 2Synonyms: IFN-gamma receptor 2, Interferon gamma receptor beta-chain
  10. Target

    Alpha-1A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000501
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1A adrenergic receptorSynonyms: Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c