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Displaying results 8371 - 8380 of 10000 in total
  1. Drug

    Paliperidone

    go.drugbank.com/drugs/DB01267
    ApprovedInvestigational

    It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. … Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug.

    Synonyms: 9-hydroxyrisperidoneCategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  2. Drug

    St. John's Wort

    go.drugbank.com/drugs/DB01323
    ApprovedNutraceutical

    Mixtures: S. R. FormulaCategories: P-glycoprotein inducers, Cytochrome P-450 Substrates
  3. Drug

    Lithium cation

    go.drugbank.com/drugs/DB01356
    ApprovedInvestigationalWithdrawn

    The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several … It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches.

  4. Drug

    Tiotropium

    go.drugbank.com/drugs/DB01409
    ApprovedInvestigational

    Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.

    Mixtures: SPIOLTO®RESPIMAT®, SPIOLTO®RESPIMAT®Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-Ring
  5. Drug

    Iron

    go.drugbank.com/drugs/DB01592
    ApprovedInvestigational

    A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems.

    Mixtures: Advanced B & T Formula, Chela Iron Plus C,b ComplexProducts: HEMBIN®, EUROFER® JARABE
  6. Drug

    Thiothixene

    go.drugbank.com/drugs/DB01623
    Approved

    A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 3-Ring
  7. Drug

    Tromethamine

    go.drugbank.com/drugs/DB03754
    ApprovedInvestigational

    It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used

    Synonyms: 2-Amino-2-(hydroxymethyl)-1,3-propanediolCategories: Compounds used in a research, industrial, or household setting
  8. Drug

    Lorcaserin

    go.drugbank.com/drugs/DB04871
    ApprovedInvestigationalWithdrawn

    This decision was based on the results of a clinical trial assessing the risk of heart-related problems that found that patients treated with lorcaserin may have a higher risk of cancer. … Lorcaserin is marketed as a salt form called Belviq, which is lorcaserin hydrochloride.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-Ring
  9. Drug

    Olaratumab

    go.drugbank.com/drugs/DB06043
    ApprovedInvestigational

    Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity … It is composed of two heavy chain molecule fragments and 2 light chain fragments.

  10. Drug

    Nylidrin

    go.drugbank.com/drugs/DB06152
    ApprovedWithdrawn

    Nylidrin is a peripheral vasodilator.

    Categories: 2-Amino-1-Phenylethanol Derivatives, Cytochrome P-450 Substrates