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Displaying results 841 - 850 of 1804 in total
  1. Target

    Cytochrome c oxidase subunit 7A1, mitochondrial

    go.drugbank.com/bio_entities/BE0003996
    TargetHumans

    Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (By similarity). The CIV complex i...

    Synonyms: Cytochrome c oxidase subunit VIIa-H, Cytochrome c oxidase subunit VIIa-M
  2. Drug

    Bromhexine

    go.drugbank.com/drugs/DB09019
    ApprovedInvestigational

    Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducin...

  3. Drug

    Ciclesonide

    go.drugbank.com/drugs/DB01410
    ApprovedInvestigational

    Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco.

  4. Target

    G protein-coupled receptor kinase 2

    go.drugbank.com/bio_entities/BE0000341
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:14976224, PubMed:16179383, PubMed:19306925, PubMed … Also able to mediate phosphorylation-independent desensitization of dopamine receptor DRD2 (By similarity)

    Polypeptides: G protein-coupled receptor kinase 2Synonyms: Beta-adrenergic receptor kinase 1
  5. Target

    Receptor tyrosine-protein kinase erbB-2

    go.drugbank.com/bio_entities/BE0000511
    TargetEnzymeHumans

    Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. … Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding.

    Polypeptides: Receptor tyrosine-protein kinase erbB-2Synonyms: Tyrosine kinase-type cell surface receptor HER2
  6. Target

    Taste receptor type 1 member 3

    go.drugbank.com/bio_entities/BE0000582
    TargetHumans

    Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). … The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359).

    Polypeptides: Taste receptor type 1 member 3Synonyms: Sweet taste receptor T1R3
  7. Target

    Insulin-like growth factor 1 receptor

    go.drugbank.com/bio_entities/BE0000858
    TargetHumans

    Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor … IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R

    Polypeptides: Insulin-like growth factor 1 receptorSynonyms: IGF-I receptor, Insulin-like growth factor I receptor
  8. Target

    C-C chemokine receptor type 5

    go.drugbank.com/bio_entities/BE0000911
    TargetHumans

    Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770) … Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.

    Polypeptides: C-C chemokine receptor type 5
  9. Target

    Growth factor receptor-bound protein 2

    go.drugbank.com/bio_entities/BE0000917
    TargetHumans

    Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702). … Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232

    Polypeptides: Growth factor receptor-bound protein 2Function: ephrin receptor binding
  10. Target

    High affinity nerve growth factor receptor

    go.drugbank.com/bio_entities/BE0001039
    TargetHumans

    Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and … High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889).

    Polypeptides: High affinity nerve growth factor receptorSynonyms: Tyrosine kinase receptor, Tyrosine kinase receptor A