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Displaying results 861 - 870 of 3735 in total
  1. Target

    Interleukin-5 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0003471
    TargetHumans

    Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). … Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124)

    Polypeptides: Interleukin-5 receptor subunit alphaSynonyms: IL-5 receptor subunit alpha
  2. Target

    Prostaglandin E2 receptor EP4 subtype

    go.drugbank.com/bio_entities/BE0003522
    TargetHumans

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle.

    Polypeptides: Prostaglandin E2 receptor EP4 subtypeSynonyms: PGE receptor EP4 subtype, Prostanoid EP4 receptor
  3. Target

    TGF-beta receptor type-1

    go.drugbank.com/bio_entities/BE0003782
    TargetHumans

    Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. … Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.

    Polypeptides: TGF-beta receptor type-1Synonyms: TGF-beta receptor type I, TGF-beta type I receptor
  4. Target

    Ephrin type-B receptor 2

    go.drugbank.com/bio_entities/BE0004549
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Polypeptides: Ephrin type-B receptor 2Synonyms: Tyrosine-protein kinase receptor EPH-3
  5. Target

    Discoidin domain-containing receptor 2

    go.drugbank.com/bio_entities/BE0004741
    TargetHumans

    It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. … Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2.

    Polypeptides: Discoidin domain-containing receptor 2Synonyms: Discoidin domain receptor 2, Receptor protein-tyrosine kinase TKT
  6. Target

    Glycine receptor (alpha-1/beta)

    go.drugbank.com/bio_entities/BE0004857
    TargetHumans

    Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contri...

    Polypeptides: Glycine receptor subunit beta, Glycine receptor subunit alpha-1Synonyms: Glycine receptor 48 kDa subunit, Glycine receptor 58 kDa subunit
  7. Target

    Sphingosine 1-phosphate receptor 1

    go.drugbank.com/bio_entities/BE0008652
    TargetHumans

    G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. … Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the

    Polypeptides: Sphingosine 1-phosphate receptor 1Synonyms: S1P receptor 1, S1P receptor Edg-1
  8. Target

    G protein-coupled receptor 12

    go.drugbank.com/bio_entities/BE0009153
    TargetHumans

    Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production (PubMed:36593162). … Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (By similarity).

    Polypeptides: G protein-coupled receptor 12Function: G protein-coupled receptor activity
  9. Target

    Tyrosine-protein kinase receptor TYRO3

    go.drugbank.com/bio_entities/BE0009404
    TargetHumans

    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6.

    Polypeptides: Tyrosine-protein kinase receptor TYRO3
  10. Target

    Ephrin type-A receptor 1

    go.drugbank.com/bio_entities/BE0009436
    TargetHumans

    The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. … Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.

    Polypeptides: Ephrin type-A receptor 1Synonyms: Tyrosine-protein kinase receptor EPH, Erythropoietin-producing hepatoma receptor