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U1 small nuclear ribonucleoprotein A
go.drugbank.com/bio_entities/BE0002708TargetHumansIn a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs
Polypeptides: U1 small nuclear ribonucleoprotein ASynonyms: U1-A, U1 snRNP ADNA topoisomerase 4 subunit A
go.drugbank.com/bio_entities/BE0003726TargetStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)Performs the decatenation events required during the replication of a circular DNA molecule.
Polypeptides: DNA topoisomerase 4 subunit ASynonyms: Topoisomerase IV subunit AMyocardin-related transcription factor A
go.drugbank.com/bio_entities/BE0004156TargetHumansTranscription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SR...
Polypeptides: Myocardin-related transcription factor ASynonyms: MRTF-AEphrin type-A receptor 5
go.drugbank.com/bio_entities/BE0005587TargetHumansAmong GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. … Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis.
Polypeptides: Ephrin type-A receptor 5Ephrin type-A receptor 4
go.drugbank.com/bio_entities/BE0009438TargetHumansIn the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. … In addition to its role in axonal guidance plays a role in synaptic plasticity.
Polypeptides: Ephrin type-A receptor 4Acyl-coenzyme A thioesterase 1
go.drugbank.com/bio_entities/BE0016368EnzymeHumansCatalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels.
Polypeptides: Acyl-coenzyme A thioesterase 1Synonyms: Palmitoyl-coenzyme A thioesterase, Inducible cytosolic acyl-coenzyme A thioester hydrolasePotassium
go.drugbank.com/drugs/DB14500ApprovedInvestigationalPotassium is an essential nutrient, like [Calcium] and [Magnesium]. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans. … Potassium is often a key ingredient for intravenous fluids, given to patients in clinical settings for rehydration, nutrition, and replenishment of electrolytes.
Mixtures: Fem Time Tab, Nutrilite Double XSynonyms: KPlasma protein fraction (human)
go.drugbank.com/drugs/DB13968ApprovedInvestigationalThe plasma protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and globulin derived from human plasma. … It is also stated that no more than 1% of the total protein should be gamma globulin.[L2260] PPFh is a sterile, frozen solution of solvent/detergent treated human plasma.
Products: OCTAPLAS Blood Group A, Octaplas SD Blutgruppe A zur InfusionPerioperative Bleeding caused by Hemophilia A
go.drugbank.com/conditions/DBCOND0089513Synonyms: Perioperative Bleeding caused by Hemophilia ABortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigationalBortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. … [A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide, [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid