Search

Displaying results 871 - 880 of 3735 in total
  1. Target

    Ephrin type-A receptor 8

    go.drugbank.com/bio_entities/BE0009440
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Polypeptides: Ephrin type-A receptor 8Synonyms: Tyrosine-protein kinase receptor EEK
  2. Target

    Ephrin type-B receptor 1

    go.drugbank.com/bio_entities/BE0009441
    TargetHumans

    Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. … Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.

    Polypeptides: Ephrin type-B receptor 1Synonyms: Tyrosine-protein kinase receptor EPH-2
  3. Target

    NT-3 growth factor receptor

    go.drugbank.com/bio_entities/BE0009501
    TargetHumans

    Receptor tyrosine kinase involved in nervous system and probably heart development.

    Polypeptides: NT-3 growth factor receptorSynonyms: Neurotrophic tyrosine kinase receptor type 3
  4. Target

    Receptor for retinol uptake STRA6

    go.drugbank.com/bio_entities/BE0009879
    TransporterHumans

    Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding prot...

    Polypeptides: Receptor for retinol uptake STRA6Synonyms: Retinol-binding protein receptor STRA6
  5. Target

    Sphingosine 1-phosphate receptor 4

    go.drugbank.com/bio_entities/BE0009882
    TargetHumans

    Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). … G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production.

    Polypeptides: Sphingosine 1-phosphate receptor 4Synonyms: S1P receptor 4, S1P receptor Edg-6
  6. Target

    C5a anaphylatoxin chemotactic receptor 1

    go.drugbank.com/bio_entities/BE0010095
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859,

    Polypeptides: C5a anaphylatoxin chemotactic receptor 1Synonyms: C5a anaphylatoxin chemotactic receptor
  7. Target

    Interferon alpha/beta receptor (IFNAR)

    go.drugbank.com/bio_entities/BE0010136
    TargetHumans

    Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461 … Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity)

    Polypeptides: Interferon alpha/beta receptor 1, Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 1, IFN-alpha/beta receptor 2
  8. Target

    Interleukin-1 receptor-like 2

    go.drugbank.com/bio_entities/BE0010198
    TargetHumans

    Receptor for interleukin-36 (IL36A, IL36B and IL36G). … After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways

    Polypeptides: Interleukin-1 receptor-like 2Synonyms: IL-36 receptor, Interleukin-1 receptor-related protein 2
  9. Target

    Interleukin-7 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0010557
    TargetHumans

    Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)

    Polypeptides: Interleukin-7 receptor subunit alphaSynonyms: IL-7 receptor subunit alpha
  10. Target

    Sphingosine 1-phosphate receptor 2

    go.drugbank.com/bio_entities/BE0012208
    TargetHumans

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). … Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).

    Polypeptides: Sphingosine 1-phosphate receptor 2Synonyms: S1P receptor 2, S1P receptor Edg-5