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Carbonic anhydrase 1
go.drugbank.com/bio_entities/BE0000267TargetEnzymeCarrierHumansCatalyzes the reversible hydration of carbon dioxide (PubMed:10550681, PubMed:16506782, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17407288, PubMed:19186056, PubMed:19206230, PubMed:4994926). Can hydrate c...
Polypeptides: Carbonic anhydrase 1Glutamate decarboxylase 1
go.drugbank.com/bio_entities/BE0000378TargetHumansCatalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor
Polypeptides: Glutamate decarboxylase 1Glutamate receptor 1
go.drugbank.com/bio_entities/BE0000640TargetHumansAlso permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity) … Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic
Polypeptides: Glutamate receptor 1Synonyms: GluR-1, AMPA-selective glutamate receptor 1Alanine aminotransferase 1
go.drugbank.com/bio_entities/BE0000667TargetHumansPyridoxal enzyme tha catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate (PubMed:11863375). By mediating the conversion of these four major intermediate metabolites, plays an importan...
Polypeptides: Alanine aminotransferase 1Synonyms: GPT-1, Glutamate pyruvate transaminase 1Monocarboxylate transporter 1
go.drugbank.com/bio_entities/BE0000669TargetTransporterHumansBidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ke...
Polypeptides: Monocarboxylate transporter 1Synonyms: MCT 1, Solute carrier family 16 member 1Alpha-1-antitrypsin
go.drugbank.com/bio_entities/BE0000952TargetCarrierHumansInhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induce...
Polypeptides: Alpha-1-antitrypsinSynonyms: Alpha-1-antiproteinase, Alpha-1 protease inhibitorDNA topoisomerase 1
go.drugbank.com/bio_entities/BE0000971TargetEnzymeHumansFinally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). … The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.
Polypeptides: DNA topoisomerase 1Phosphatidylserine synthase 1
go.drugbank.com/bio_entities/BE0001099TargetHumansCatalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylchol...
Polypeptides: Phosphatidylserine synthase 1Synonyms: PSS-1, PtdSer synthase 1GMP reductase 1
go.drugbank.com/bio_entities/BE0001376TargetHumansCatalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucl...
Polypeptides: GMP reductase 1Synonyms: Guanosine 5'-monophosphate oxidoreductase 1, GMPR 1Aspartate 1-decarboxylase
go.drugbank.com/bio_entities/BE0001513TargetShigella flexneriCatalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Polypeptides: Aspartate 1-decarboxylaseFunction: aspartate 1-decarboxylase activity