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Displaying results 881 - 890 of 1809 in total
  1. Target

    Adhesion G protein-coupled receptor D1

    go.drugbank.com/bio_entities/BE0005510
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271)

    Polypeptides: Adhesion G protein-coupled receptor D1Synonyms: G protein-coupled receptor 133, G protein-coupled receptor PGR25
  2. Target

    Signal recognition particle receptor subunit beta

    go.drugbank.com/bio_entities/BE0009230
    TargetPlasmodium falciparum (isolate 3D7)

    Polypeptides: Signal recognition particle receptor subunit betaSynonyms: Signal recognition particle receptor, beta subunit
  3. Target

    Tyrosine-protein kinase receptor Tie-1

    go.drugbank.com/bio_entities/BE0009396
    TargetHumans

    Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis

    Polypeptides: Tyrosine-protein kinase receptor Tie-1
  4. Target

    Interleukin-1 receptor-associated kinase 3

    go.drugbank.com/bio_entities/BE0009453
    TargetHumans

    Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).

    Polypeptides: Interleukin-1 receptor-associated kinase 3Synonyms: IL-1 receptor-associated kinase M, Inactive IL-1 receptor-associated kinase 3
  5. Target

    C-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0009787
    TargetHumans

    High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. … The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system.

    Polypeptides: C-C chemokine receptor type 4
  6. Target

    Killer cell immunoglobulin-like receptor 2DL3

    go.drugbank.com/bio_entities/BE0010665
    TargetHumans

    Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis

    Polypeptides: Killer cell immunoglobulin-like receptor 2DL3Synonyms: p58 NK receptor CL-6, Killer inhibitory receptor cl 2-3
  7. Target

    Baculoviral IAP repeat-containing protein 3

    go.drugbank.com/bio_entities/BE0010674
    TargetHumans

    Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition

    Polypeptides: Baculoviral IAP repeat-containing protein 3
  8. Target

    Baculoviral IAP repeat-containing protein 2

    go.drugbank.com/bio_entities/BE0010675
    TargetHumans

    Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition

    Polypeptides: Baculoviral IAP repeat-containing protein 2
  9. Target

    Ciliary neurotrophic factor receptor subunit alpha

    go.drugbank.com/bio_entities/BE0012974
    TargetHumans

    Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including … Functions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR

    Polypeptides: Ciliary neurotrophic factor receptor subunit alphaSynonyms: CNTF receptor subunit alpha
  10. Target

    G protein-coupled receptor kinase 5

    go.drugbank.com/bio_entities/BE0013072
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. … Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro)

    Polypeptides: G protein-coupled receptor kinase 5Synonyms: G protein-coupled receptor kinase GRK5