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Potassium voltage-gated channel subfamily A member 10
go.drugbank.com/bio_entities/BE0004720TargetHumansVoltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. … When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the membrane down their electrochemical gradient
Polypeptides: Potassium voltage-gated channel subfamily A member 10Synonyms: Voltage-gated potassium channel subunit Kv1.8Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
go.drugbank.com/bio_entities/BE0004631TargetHumansHyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). … Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity).
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
go.drugbank.com/bio_entities/BE0010899TargetHumansHyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). … Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409).
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
go.drugbank.com/bio_entities/BE0020615TargetHumansHyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). … Contributes to the native pacemaker currents in heart (If) and in neurons (Ih).
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3Function: voltage-gated potassium channel activityPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
go.drugbank.com/bio_entities/BE0021454TargetHumansHyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation (PubMed:10228147, PubMed:10430953, PubMed:20829353).
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
go.drugbank.com/bio_entities/BE0001300TargetHumansMay act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K
Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositideSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
go.drugbank.com/bio_entities/BE0000423TargetTransporterHumansTransports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). … Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766)
Polypeptides: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)B- and T-lymphocyte attenuator
go.drugbank.com/bio_entities/BE0010629TargetHumansInhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). … In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.
Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated proteinSplicing factor, proline- and glutamine-rich
go.drugbank.com/bio_entities/BE0008965TargetHumansThe SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. … DNA- and RNA binding protein, involved in several nuclear processes.
Polypeptides: Splicing factor, proline- and glutamine-richCocaine- and amphetamine-regulated transcript protein
go.drugbank.com/bio_entities/BE0000867TargetHumansSatiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced … It promotes neuronal development and survival in vitro
Polypeptides: Cocaine- and amphetamine-regulated transcript protein