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Thioridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126560Drug actionThioridazine is a trifluoro-methyl phenothiazine derivative. Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal...
Enzymes: Sodium-dependent serotonin transporterBromopride Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126582Drug actionBromopride is a substituted benzamide. Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation an...
Enzymes: Sodium-dependent dopamine transporterPaliperidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126592Drug actionPaliperidone is the primary active metabolite of risperidone. The two antipsychotics are also metabolized differently, as risperidone is metabolized in the liver mainly by the polymorphic cytochrome P450 2D6 (CYP2D6) to its active metabo...
Enzymes: Sodium-dependent dopamine transporterDosulepin Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126779Drug actionDosulepin is indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Dosulepin displays affinity towards α2-adrenoceptors and to a lesser extent, α1-adrenoceptors. Inhibition of ...
Enzymes: Sodium-dependent serotonin transporterGranisetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126787Drug actionGranisetron is a selective inhibitor of type 3 serotonergic (5-HT3) receptors. Granisetron has little or no affinity for other serotonin receptors, including 5-HT 1 , 5-HT 1A , 5-HT 1B/C , or 5-HT 2 ; for alpha 1 -, alpha 2 -, or beta-ad...
Enzymes: Sodium-dependent serotonin transporterQuetiapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126799Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Enzymes: Sodium-dependent serotonin transporterLorpiprazole Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126822Drug actionLorpiprazole is a serotonin antagonist and reuptake inhibitor thus, its activity is performed by antagonizing the 5-HT2A and the 5-HT2C serotoninergic receptors as well as the alpha1 and alpha2 adrenergic receptors, H1 histaminergic rece...
Enzymes: Sodium-dependent serotonin transporterCyclobenzaprine Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126845Drug actionCyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepressants. Cyclobenzaprine relieves skeletal muscle spasms of local origin without interfering with muscle function. In preclinical re...
Enzymes: Sodium-dependent serotonin transporterClozapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0125311Drug actionClozapine is an antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Clozapine is available as oral tablets. Clozapine is part of a group of drugs known as second-generation...
Enzymes: Sodium-dependent serotonin transporterPromazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126483Drug actionPromazine is used as an adjunct for short term treatment of moderate and severe psychomotor agitation. It is also used to treat agitation or restlessness in the elderly. Promazine is an antagonist at types 1, 2, and 4 dopamine receptors,...
Enzymes: Sodium-dependent dopamine transporter