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Displaying results 891 - 900 of 10000 in total
  1. Pathway

    Methionine Adenosyltransferase Deficiency

    smpdb.ca/view/SMP0125683
    Disease

    Methionine adenosyltransferase (MAT; Hypermethioninemia; MAT I/III deficiency) deficiency is caused by mutations in the MAT1A gene which causes isolated hypermethioninemia. MAT catalyzes the formation of adenosylmethionine from methionin...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  2. Indication

    Diabetic Ketoacidosis

    go.drugbank.com/conditions/DBCOND0000979
    Drugs: Insulin aspart · Insulin degludec · Insulin detemir · Insulin lispro · Metformin · Somatostatin
  3. Target

    Cyclopropane mycolic acid synthase 1

    go.drugbank.com/bio_entities/BE0003738
    TargetMycobacterium tuberculosis

    Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine.

    Synonyms: S-adenosylmethionine-dependent methyltransferase
  4. Drug

    Ascorbic acid

    go.drugbank.com/drugs/DB00126
    ApprovedInvestigationalNutraceutical

    Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. … A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables.

    Synonyms: Vitamin C, Vitamin-CMixtures: Genicin Vita-S, Kordel"s Kid"s Multivitamins Plus Lysine Chewable Tablet
  5. Pathway

    Glycine N-Methyltransferase Deficiency

    smpdb.ca/view/SMP0125681
    Disease

    GNMT catalyzes the conversion of glycine into N-methylglycine (sarcosine) using S-adenosylmethionine (SAM or AdoMet).

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  6. Target

    Cyclopropane mycolic acid synthase 2

    go.drugbank.com/bio_entities/BE0001211
    TargetMycobacterium tuberculosis

    cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine

    Synonyms: S-adenosylmethionine-dependent methyltransferase
  7. Pathway

    Hypermethioninemia

    smpdb.ca/view/SMP0125679
    Disease

    This gene is responsible for Adenosylhomocysteinase, an enzyme which takes S-adenosyl homocysteine as input, and produces homocysteine as its output.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  8. Indication

    Cardiovascular Risk

    go.drugbank.com/conditions/DBCOND0039927
    Drugs: Acetylsalicylic acid · Atorvastatin · Dapagliflozin · Dulaglutide · Icosapent ethyl · Metformin +1 more
  9. Indication

    High risk for progression to severe disease

    go.drugbank.com/conditions/DBCOND0143965
    Drugs: Anakinra · Dapagliflozin · Empagliflozin · Imdevimab · Metformin · Nirmatrelvir +3 more
  10. Drug

    Dibenzepin

    go.drugbank.com/drugs/DB13225
    Approved

    Dibenzepin is approved for use in Europe.

    Categories: Heterocyclic Compounds, 3-Ring