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Displaying results 891 - 900 of 3735 in total
  1. Drug

    Apixaban

    go.drugbank.com/drugs/DB06605
    ApprovedInvestigational

    Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. ...

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  2. Drug

    Sodium hydroxide

    go.drugbank.com/drugs/DB11151
    Approved

    According to the the FDA, sodium hydroxide is considered a direct food recognized as safe, where it serves as a pH control agent and follows good manufacturing guidelines [L1967].

  3. Target

    Peroxisome proliferator-activated receptor alpha

    go.drugbank.com/bio_entities/BE0000071
    TargetHumans

    Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids.

    Polypeptides: Peroxisome proliferator-activated receptor alphaSynonyms: Nuclear receptor subfamily 1 group C member 1
  4. Target

    Glutamate receptor ionotropic, NMDA 1

    go.drugbank.com/bio_entities/BE0000365
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26...

    Polypeptides: Glutamate receptor ionotropic, NMDA 1Synonyms: Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1
  5. Target

    Glutamate receptor ionotropic, NMDA 2D

    go.drugbank.com/bio_entities/BE0000396
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:27616483, PubMed:28...

    Polypeptides: Glutamate receptor ionotropic, NMDA 2DSynonyms: N-methyl D-aspartate receptor subtype 2D, Glutamate [NMDA] receptor subunit epsilon-4
  6. Target

    Glycine receptor subunit alpha-3

    go.drugbank.com/bio_entities/BE0000414
    TargetHumans

    Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:26416729, PubMed:9677400). Channel characteristics depend on the subunit composition; heteropentameric channels display f...

    Polypeptides: Glycine receptor subunit alpha-3
  7. Target

    Activin receptor type-1-like

    go.drugbank.com/bio_entities/BE0000459
    TargetHumans

    Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

    Polypeptides: Activin receptor type-1-likeSynonyms: Activin receptor-like kinase 1, TGF-B superfamily receptor type I
  8. Target

    Interleukin-1 receptor type 1

    go.drugbank.com/bio_entities/BE0000565
    TargetHumans

    Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. … Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560).

    Polypeptides: Interleukin-1 receptor type 1Synonyms: Interleukin-1 receptor alpha, Interleukin-1 receptor type I
  9. Target

    Growth hormone-releasing hormone receptor

    go.drugbank.com/bio_entities/BE0000625
    TargetHumans

    Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion

    Polypeptides: Growth hormone-releasing hormone receptorSynonyms: GRF receptor, GHRH receptor
  10. Target

    Glutamate receptor ionotropic, NMDA 3A

    go.drugbank.com/bio_entities/BE0000641
    TargetHumans

    Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:38598639). … Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity).

    Polypeptides: Glutamate receptor ionotropic, NMDA 3ASynonyms: N-methyl-D-aspartate receptor subtype 3A