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Displaying results 891 - 900 of 1994 in total
  1. Pathway

    Fluvastatin Action Pathway (New)

    smpdb.ca/view/SMP0124569
    Drug action

    Statins bind reversibly to the active site of HMG-CoA reductase and the subsequent structural change in the enzyme effectively disables it. … Reported side effects of fluvastatin include gastrointestinal upset (diarrhea, nausea, constipation, gas, abdominal pain), myotoxicity (myopathy, myositis, rhabdomyolysis), and hepatotoxicity.

    Drugs: Fluvastatin · Calcium · Zinc · Cholesterol
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease
  2. Drug

    Erythromycin

    go.drugbank.com/drugs/DB00199
    ApprovedInvestigationalVet approved

    Erythromycin is a bacteriostatic antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics which consists of Azithromycin, Clarithromycin, Spi...

    Products: Sterile Erythromycin Lactobionate Pws 1000mg, Ees 600 Tablets 600mg
  3. Target

    POU domain, class 5, transcription factor 1

    go.drugbank.com/bio_entities/BE0003665
    TransporterTargetHumans

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP...

    Polypeptides: POU domain, class 5, transcription factor 1
  4. Drug

    Pralidoxime

    go.drugbank.com/drugs/DB00733
    ApprovedInvestigationalVet approved

    Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme.

    Products: PAMPARA INJECTION 500mg/20ml
  5. Drug

    Azatadine

    go.drugbank.com/drugs/DB00719
    ApprovedWithdrawn

    Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. … The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury

  6. Indication

    Still's Disease

    go.drugbank.com/conditions/DBCOND0066232
    Drugs: Tetracosactide
    Synonyms: Juvenile rheumatoid arthritis with systemic onset, unspecified site
  7. Drug

    Lysine

    go.drugbank.com/drugs/DB00123
    ApprovedInvestigationalNutraceutical

    The ε-amino group acts as a site for hydrogen binding and a general base in catalysis.

    Mixtures: Champs Vitamin C 100mg Plus Lysine Fruity Flavour Chewable Tablet, PROCALAMINE SISE 500 ML(SETLI)
  8. Drug

    Cefdinir

    go.drugbank.com/drugs/DB00535
    ApprovedInvestigational

    Cefdinir, also known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third generation of the cephalosporin class. It has been proven to be effective for the treatment of common bacterial infections in the ear,...

    Products: ASEMAX 250MG/5ML ORAL SUSPANSIYON HAZIRLAMAK ICIN KURU TOZ, 100ML, TAMCEF 600MG EFERVESAN TABLET, 20 ADET
  9. Drug

    Mometasone furoate

    go.drugbank.com/drugs/DB14512
    ApprovedInvestigationalVet approved

    Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label] . It has a glucocorticoid receptor binding affinity 22 times stronger than dexamethasone and highe...

    Products: Asmanex Twisthaler 100mcg/inhalation
  10. Indication

    Mast Cell Leukemia (MCL)

    go.drugbank.com/conditions/DBCOND0076279
    Drugs: Avapritinib · Midostaurin
    Synonyms: Mast cell malignancy of unspecified site (disorder)