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Displaying results 891 - 900 of 10000 in total
  1. Drug

    Lormetazepam

    go.drugbank.com/drugs/DB13872
    Approved

    Lormatazepam is an orally available benzodiazepine used in the UK for the treatment of short-term insomnia [L927]. … It is marketed by Auden Mckenzie (Pharma Division) in 0.5 and 1 mg tablet formulations.

    Categories: Hypnotics and Sedatives, Benzodiazepines and benzodiazepine derivativesSynonyms: N-Methyllorazepam
  2. Pathway

    D-Arginine and D-Ornithine Metabolism

    smpdb.ca/view/SMP0000036
    Metabolic

    D-Amino may have negative effects as they can be found in some bacteria or form spontaneously in certain reactions. … D-Amino acids have been show to be present in high concentrations in humans and play a role in biological functions.

    Drugs: 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate · Flavin adenine dinucleotide · Urea
  3. Pathway

    Metabolism and Physiological Effects of Phenylacetylglutamine

    smpdb.ca/view/SMP0123208
    Metabolic

    Phenylacetylglutamine is a normal constituent of human urine, but other mammals such as the dog, cat, rat, monkey, sheep, and horse do not excrete this compound. … Phenylacetylglutamine is a microbial metabolite found in Christensenellaceae, Lachnospiraceae and Ruminococcaceae.

    Drugs: Phenylalanine · L-Glutamine · Adenosine phosphate · ATP · Magnesium cation · Phenylpyruvic acid +1 more
  4. Pathway

    Metabolism and Physiological Effects of Phenol

    smpdb.ca/view/SMP0123255
    Metabolic

    Phenol can get further metabolized in a liver hepatocyte to Phenyl sulphate and Phenyl glucuronide. However phenol itself is shown to be a major uremic toxin through high levels of retention. … Phenol is shown to cause cardiovascular disease and enhance the production of reactive oxygen species and cause oxidative stress.

    Drugs: Tyrosine · Phenol
  5. Pathway

    Metabolism and Physiological Effects of Choline

    smpdb.ca/view/SMP0124739
    Metabolic

    The toxicity of choline is due to the formation of TMA and its metabolism to Trimethylamine N-oxide (TMAO) in the liver. … In the intestine, choline is metabolized to other products such as acetylcholine, betaine, phosphatidylcholine and trimethylamine (TMA) by the gut microbiota.

    Drugs: Choline · Flavin adenine dinucleotide
  6. Pathway

    Metabolism and Physiological Effects of Dimethylglycine

    smpdb.ca/view/SMP0124873
    Metabolic

    Dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. … Dimethylglycine enters the bloodstream and can cause toxic effects on the cardiovascular system.

    Drugs: Choline · Methionine · NADH · Zinc · N,N-dimethylglycine · Flavin adenine dinucleotide +1 more
  7. Pathway

    Metabolism and Physiological Effects of Phenylacetylglycine

    smpdb.ca/view/SMP0126858
    Metabolic

    In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. … Phenylacetic acid is used in some perfumes, possessing a honey-like odour in low concentrations, and is also used in penicillin G production. PAG is a putative biomarker of phospholipidosis.

    Drugs: Glycine
  8. Drug

    Prazosin

    go.drugbank.com/drugs/DB00457
    ApprovedInvestigational

    Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. … Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTSD) and associated nightmares.[A176618, A176621, A176624]

    Categories: prazosin and diuretics, Alpha-Adrenoreceptor Antagonists and DiureticsProducts: Nu-prazo Tab 5mg, MINIPRESS TABLET 5MG
  9. Drug

    Tixocortol

    go.drugbank.com/drugs/DB09091
    ApprovedWithdrawn

    It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and mineralocorticoid activities and toxicity.[L1078] … Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid.

    Categories: Alimentary Tract and Metabolism, Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: Rectovalone 250mg/100ml
  10. Drug

    Zolpidem

    go.drugbank.com/drugs/DB00425
    ApprovedInvestigational

    In addition, zolpidem improves sleep quality in patients suffering from chronic insomnia and can show mild muscle relaxant properties [L5584]. … Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia.

    Synonyms: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamideCategories: Hypnotics and Sedatives, Benzodiazepine hypnotics and sedatives