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Ephrin type-B receptor 2
go.drugbank.com/bio_entities/BE0004549TargetHumansReceptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Polypeptides: Ephrin type-B receptor 2Synonyms: Tyrosine-protein kinase receptor EPH-3Discoidin domain-containing receptor 2
go.drugbank.com/bio_entities/BE0004741TargetHumansIt functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. … Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2.
Polypeptides: Discoidin domain-containing receptor 2Synonyms: Discoidin domain receptor 2, Receptor protein-tyrosine kinase TKTGlycine receptor (alpha-1/beta)
go.drugbank.com/bio_entities/BE0004857TargetHumansSubunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contri...
Polypeptides: Glycine receptor subunit beta, Glycine receptor subunit alpha-1Synonyms: Glycine receptor 48 kDa subunit, Glycine receptor 58 kDa subunitSphingosine 1-phosphate receptor 1
go.drugbank.com/bio_entities/BE0008652TargetHumansG protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. … Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the
Polypeptides: Sphingosine 1-phosphate receptor 1Synonyms: S1P receptor 1, S1P receptor Edg-1G protein-coupled receptor 12
go.drugbank.com/bio_entities/BE0009153TargetHumansFunctions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production (PubMed:36593162). … Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (By similarity).
Polypeptides: G protein-coupled receptor 12Function: G protein-coupled receptor activityTyrosine-protein kinase receptor TYRO3
go.drugbank.com/bio_entities/BE0009404TargetHumansReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6.
Polypeptides: Tyrosine-protein kinase receptor TYRO3Ephrin type-A receptor 1
go.drugbank.com/bio_entities/BE0009436TargetHumansThe signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. … Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-A receptor 1Synonyms: Tyrosine-protein kinase receptor EPH, Erythropoietin-producing hepatoma receptorEphrin type-A receptor 8
go.drugbank.com/bio_entities/BE0009440TargetHumansReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Polypeptides: Ephrin type-A receptor 8Synonyms: Tyrosine-protein kinase receptor EEKEphrin type-B receptor 1
go.drugbank.com/bio_entities/BE0009441TargetHumansCognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. … Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-B receptor 1Synonyms: Tyrosine-protein kinase receptor EPH-2NT-3 growth factor receptor
go.drugbank.com/bio_entities/BE0009501TargetHumansReceptor tyrosine kinase involved in nervous system and probably heart development.
Polypeptides: NT-3 growth factor receptorSynonyms: Neurotrophic tyrosine kinase receptor type 3