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Glutathione Synthetase Deficiency
smpdb.ca/view/SMP0000337DiseaseGlutathione Synthetase Deficiency (5-Oxoprolinuria; Pyroglutamic Aciduria; GSD) is a rare inborn error of metabolism (IEM) which arises from a disfunctional gene called GSS. This gene is responsible for glutathione synthetase. Glutathion...
Enzymes: Glutathione S-transferase omega-25-Oxoprolinuria
smpdb.ca/view/SMP0125615Disease5-Oxoprolinuria (5-Oxoprolinase deficiency) is a result of a defect in the gamma-glutamyl cycle due to either 5-oxoprolinase or glutathione synthetase deficiency. In the case of glutathione synthetase deficiency, the glycine is not incor...
Enzymes: Glutathione S-transferase omega-2gamma-Glutamyltranspeptidase Deficiency
smpdb.ca/view/SMP0125618DiseaseGamma-glutamyltranspeptidase deficiency, characterized by glutathionemia and glutathionuria, is an autosomal recessive disorder of glutathione metabolism caused by a defective gamma-glutamyl transpeptidase (GGT). GGT transfers glutamyl m...
Enzymes: Glutathione S-transferase omega-2Metformin
go.drugbank.com/drugs/DB00331ApprovedInvestigationalIt is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.
Mixtures: AMARYL® M SR, AMARYL® M SRCategories: MATE 1 Substrates, MATE 2 SubstratesStiripentol
go.drugbank.com/drugs/DB09118ApprovedInvestigational[A19739] Approved in the US, Canada, and Europe, stiripentol is used to treat seizures associated with Dravet syndrome.[L880,L42500,L42510] It is marketed under the brand name Diacomit. … Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.
Categories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein inhibitorsSynonyms: 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol, 4,4-Dimethyl-1-((3,4-methylenedioxy)phenyl)-1-penten-3-olIsopropyl alcohol
go.drugbank.com/drugs/DB02325ApprovedInvestigationalAn isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
Mixtures: Anesthesia S/I-60, Anesthesia S/I-40Categories: Compounds used in a research, industrial, or household settingCarboprost tromethamine Action Pathway
smpdb.ca/view/SMP0127007Drug actionCarboprost tromethamine is a medication primarily used in obstetrics and gynecology for two distinct purposes. First, it is employed as an abortifacient agent in the second trimester of pregnancy, typically between the 13th and 20th week...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Alprostadil Action Pathway
smpdb.ca/view/SMP0127008Drug actionAlprostadil is a medication used for two distinct purposes. First, it is employed in the treatment of erectile dysfunction in men for whom oral treatment is either contraindicated or ineffective. It can be administered either through an ...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Glycol salicylate
go.drugbank.com/drugs/DB11323ApprovedGlycol salicylate (GS), composed of salicylic acid (SA) and ethylene glycol, is a non-steroidal anti-inflammatory drug [L2687]. … Glycol salicylate, also known as _2-hydroxyethyl salicylate_, is a benzoate ester formed from the condensation of the carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol.
Mixtures: Nopen Hot, Nopen CoolSynonyms: 2-hydroxyethyl 2-oxidanylbenzoate, 2-hydroxybenzoic acid 2-hydroxyethyl esterIloprost Action Pathway
smpdb.ca/view/SMP0126507Drug actionIloprost is a prostacyclin analog also known as Ventavis, that acts to prevent platelet aggregation. It is a second-generation analog that is structurally similar to prostacyclin. It binds to prostacyclin receptors that activate adenylyl...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1