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Displaying results 921 - 930 of 1993 in total
  1. Target

    Orexin/Hypocretin receptor type 1

    go.drugbank.com/bio_entities/BE0005864
    TargetHumans

    In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (PubMed:15683363, PubMed:32669442). … G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin (PubMed:32669442, PubMed

    Polypeptides: Orexin/Hypocretin receptor type 1Synonyms: Orexin receptor type 1, Hypocretin receptor type 1
  2. Target

    Corticotropin-releasing hormone receptor 1

    go.drugbank.com/bio_entities/BE0008658
    TargetHumans

    G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:18292205, PubMed:18801728, PubMed:20966082, PubMed:23576434, PubMed:23863939

    Polypeptides: Corticotropin-releasing hormone receptor 1Synonyms: Corticotropin-releasing factor receptor 1
  3. Target

    Ephrin type-A receptor 3

    go.drugbank.com/bio_entities/BE0009437
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (PubMed:11870224, PubMed

    Polypeptides: Ephrin type-A receptor 3Synonyms: Tyrosine-protein kinase receptor ETK1
  4. Target

    Ephrin type-A receptor 6

    go.drugbank.com/bio_entities/BE0009439
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)

    Polypeptides: Ephrin type-A receptor 6
  5. Target

    Sphingosine 1-phosphate receptor 3

    go.drugbank.com/bio_entities/BE0009881
    TargetHumans

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

    Polypeptides: Sphingosine 1-phosphate receptor 3Synonyms: S1P receptor 3, S1P receptor Edg-3
  6. Target

    Interleukin-6 receptor subunit beta

    go.drugbank.com/bio_entities/BE0010013
    TargetHumans

    Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric … Binding of cytokines, such as IL6 or IL11 to the alpha-chains of their specific cell surface receptor triggers homodimerization of IL6ST/gp130 (PubMed:19915009, PubMed:2261637, PubMed:23294003, PubMed:

    Polypeptides: Interleukin-6 receptor subunit betaSynonyms: IL-6 receptor subunit beta, Oncostatin-M receptor subunit alpha
  7. Target

    Free fatty acid receptor 2

    go.drugbank.com/bio_entities/BE0010131
    TargetHumans

    Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016) … G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis

    Polypeptides: Free fatty acid receptor 2Synonyms: G protein-coupled receptor 43
  8. Target

    Uracil nucleotide/cysteinyl leukotriene receptor

    go.drugbank.com/bio_entities/BE0010169
    TargetHumans

    Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase.

    Polypeptides: Uracil nucleotide/cysteinyl leukotriene receptorSynonyms: P2Y-like receptor, UDP/CysLT receptor
  9. Target

    Platelet-derived growth factor receptor

    go.drugbank.com/bio_entities/BE0010249
    TargetHumans

    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor

    Polypeptides: Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor betaSynonyms: Alpha platelet-derived growth factor receptor, Platelet-derived growth factor receptor 2
  10. Target

    Aryl hydrocarbon receptor nuclear translocator

    go.drugbank.com/bio_entities/BE0010296
    TargetHumans

    Forms heterodimers with the aryl hydrocarbon receptor (AHR) to mediate the transcriptional response to xenobiotics by binding xenobiotic response elements (XREs) or dioxin response elements (DREs) in target

    Polypeptides: Aryl hydrocarbon receptor nuclear translocatorSynonyms: Dioxin receptor, nuclear translocator