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Tyrosine-protein phosphatase non-receptor type 1
go.drugbank.com/bio_entities/BE0000623TargetHumansMay also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET
Polypeptides: Tyrosine-protein phosphatase non-receptor type 1C-X-C chemokine receptor type 4
go.drugbank.com/bio_entities/BE0000919TargetHumansLigand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059).
Polypeptides: C-X-C chemokine receptor type 4Synonyms: SDF-1 receptor, Stromal cell-derived factor 1 receptorLow-density lipoprotein receptor-related protein 2
go.drugbank.com/bio_entities/BE0000942TargetTransporterHumansIn the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). … Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity).
Polypeptides: Low-density lipoprotein receptor-related protein 2Tumor necrosis factor receptor superfamily member 5
go.drugbank.com/bio_entities/BE0001196TargetHumansReceptor for TNFSF5/CD40LG (PubMed:31331973).
Polypeptides: Tumor necrosis factor receptor superfamily member 5Synonyms: CD40L receptorProlow-density lipoprotein receptor-related protein 1
go.drugbank.com/bio_entities/BE0002110TargetHumansActs as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). … Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371)
Polypeptides: Prolow-density lipoprotein receptor-related protein 1Synonyms: Apolipoprotein E receptor, Alpha-2-macroglobulin receptorGamma-aminobutyric acid receptor subunit beta-3
go.drugbank.com/bio_entities/BE0002345TargetHumansBeta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:18514161, PubMed:22243422, PubMed:22303015, PubMed:2490...
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-3Synonyms: GABA(A) receptor subunit beta-3Tumor necrosis factor receptor superfamily member 10B
go.drugbank.com/bio_entities/BE0003433TargetHumansReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 10BSynonyms: Death receptor 5, TRAIL receptor 2Tumor necrosis factor receptor superfamily member 9
go.drugbank.com/bio_entities/BE0003463TargetHumansReceptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable)
Polypeptides: Tumor necrosis factor receptor superfamily member 9Synonyms: 4-1BB ligand receptorGamma-aminobutyric acid receptor subunit gamma-3
go.drugbank.com/bio_entities/BE0003594TargetHumansGamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GA...
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-3Synonyms: GABA(A) receptor subunit gamma-3Acetylcholine receptor subunit alpha-type unc-38
go.drugbank.com/bio_entities/BE0004925TargetCaenorhabditis elegansAlpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:15990870, PubMed:20027209, PubMed:9221782).
Polypeptides: Acetylcholine receptor subunit alpha-type unc-38