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Displaying results 9491 - 9500 of 10000 in total
  1. Target

    DNA ligase 1

    go.drugbank.com/bio_entities/BE0000199
    TargetHumans

    DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination

    Polypeptides: DNA ligase 1Synonyms: Polydeoxyribonucleotide synthase [ATP] 1
  2. Target

    AMP deaminase 1

    go.drugbank.com/bio_entities/BE0000352
    EnzymeHumans

    AMP deaminase plays a critical role in energy metabolism

    Polypeptides: AMP deaminase 1
  3. Target

    Serine palmitoyltransferase 1

    go.drugbank.com/bio_entities/BE0000441
    TargetHumans

    Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form lon...

    Polypeptides: Serine palmitoyltransferase 1Synonyms: LCB 1, SPT 1
  4. Target

    Endothelin-1 receptor

    go.drugbank.com/bio_entities/BE0000521
    TargetHumans

    The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 … Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    Polypeptides: Endothelin-1 receptorSynonyms: ET-A
  5. Target

    Lithostathine-1-alpha

    go.drugbank.com/bio_entities/BE0000912
    TargetHumans

    Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration

    Polypeptides: Lithostathine-1-alphaSynonyms: REG-1-alpha, Regenerating islet-derived protein 1-alpha
  6. Target

    Catenin beta-1

    go.drugbank.com/bio_entities/BE0000985
    TargetHumans

    Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a comp...

    Polypeptides: Catenin beta-1
  7. Target

    Interleukin-1 beta

    go.drugbank.com/bio_entities/BE0001051
    TargetHumans

    Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).

    Polypeptides: Interleukin-1 betaSynonyms: IL-1 beta
  8. Target

    GTP cyclohydrolase 1

    go.drugbank.com/bio_entities/BE0001055
    TargetEnzymeHumans

    Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown

    Polypeptides: GTP cyclohydrolase 1
  9. Target

    Inositol monophosphatase 1

    go.drugbank.com/bio_entities/BE0001152
    TargetHumans

    Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:17068342 … Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate (PubMed:9462881)

    Polypeptides: Inositol monophosphatase 1Synonyms: Inositol-1(or 4)-monophosphatase 1, IMP 1
  10. Target

    Pteridine reductase 1

    go.drugbank.com/bio_entities/BE0001467
    TargetLeishmania major

    Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).

    Polypeptides: Pteridine reductase 1