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Displaying results 951 - 960 of 10000 in total
  1. Pathway

    Lysophosphatidic Acid LPA6 Signalling

    smpdb.ca/view/SMP0063759
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. All six receptors belong to the G protein-coupled r...

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
  2. Drug

    Fusidic acid

    go.drugbank.com/drugs/DB02703
    ApprovedInvestigational

    (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. … It is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections.

    Mixtures: FUCIDIN H %2 + %1 KREM, 30 G, FUCICORT 20 MG/G + 1 MG/G KREM, 30 GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors
  3. Pathway

    Muscular Gs Protein Cascade

    smpdb.ca/view/SMP0126976
    Physiological

    G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their...

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  4. Drug

    Raltegravir

    go.drugbank.com/drugs/DB06817
    ApprovedInvestigational

    Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. … Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.

    Categories: Heterocyclic Compounds, 1-RingProducts: ISENTRESS® 600MG TABLETAS, ISENTRESS-G TABLET 400MG
  5. Pathway

    Thioguanine Action Pathway

    smpdb.ca/view/SMP0122727
    Drug action

    Thioguanine is an antineoplastic compound used to treat acute leukemia. It is usually administered orally and delivered to the site of action through the blood. Thioguanine has similar properties to 6-mercaptopurine as they share similar...

    Drugs: Ademetionine · ATP · Tioguanine · Magnesium cation · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Pyrophosphoric acid
    Enzymes: Thiopurine S-methyltransferase
  6. Drug

    Dipivefrin

    go.drugbank.com/drugs/DB00449
    ApprovedWithdrawn

    Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).

    Synonyms: 1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol, (±)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalateInternational brands: D Epifrin
  7. Pathway

    Treprostinil Action Pathway

    smpdb.ca/view/SMP0126517
    Drug action

    Treprostinil is a stable tricyclic analogue of prostacyclin, it promotes vasodilation and inhibition of platelet aggregation. Treprostinil is administered either subcutaneously, orally or through inhalation used to treat pulmonary arteri...

    Drugs: Treprostinil · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  8. Target

    Mitogen-activated protein kinase kinase kinase 1

    go.drugbank.com/bio_entities/BE0003430
    TargetHumans

    Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Ac...

    Synonyms: MEKK, MEKK 1
  9. Pathway

    Lysophosphatidic Acid LPA3 Signalling

    smpdb.ca/view/SMP0063755
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. All six receptors belong to the G protein-coupled r...

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
  10. Drug

    Methylphenobarbital

    go.drugbank.com/drugs/DB00849
    Approved

    A barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.

    Synonyms: 5-ethyl-1-methyl-5-phenylbarbituric acid, 5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trioneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers