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Displaying results 961 - 970 of 1993 in total
  1. Target

    Interleukin-6 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0002859
    TargetHumans

    Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST.

    Polypeptides: Interleukin-6 receptor subunit alphaSynonyms: IL-6 receptor subunit alpha
  2. Target

    Signal recognition particle receptor FtsY

    go.drugbank.com/bio_entities/BE0003264
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).

    Polypeptides: Signal recognition particle receptor FtsYSynonyms: SRP receptor
  3. Target

    Interleukin-5 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0003471
    TargetHumans

    Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). … Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124)

    Polypeptides: Interleukin-5 receptor subunit alphaSynonyms: IL-5 receptor subunit alpha
  4. Target

    Prostaglandin E2 receptor EP4 subtype

    go.drugbank.com/bio_entities/BE0003522
    TargetHumans

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle.

    Polypeptides: Prostaglandin E2 receptor EP4 subtypeSynonyms: PGE receptor EP4 subtype, Prostanoid EP4 receptor
  5. Target

    TGF-beta receptor type-1

    go.drugbank.com/bio_entities/BE0003782
    TargetHumans

    Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. … Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.

    Polypeptides: TGF-beta receptor type-1Synonyms: TGF-beta receptor type I, TGF-beta type I receptor
  6. Target

    Ephrin type-B receptor 2

    go.drugbank.com/bio_entities/BE0004549
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Polypeptides: Ephrin type-B receptor 2Synonyms: Tyrosine-protein kinase receptor EPH-3
  7. Target

    Discoidin domain-containing receptor 2

    go.drugbank.com/bio_entities/BE0004741
    TargetHumans

    It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation.

    Polypeptides: Discoidin domain-containing receptor 2Synonyms: Discoidin domain receptor 2, Receptor protein-tyrosine kinase TKT
  8. Target

    Glycine receptor (alpha-1/beta)

    go.drugbank.com/bio_entities/BE0004857
    TargetHumans

    Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contri...

    Polypeptides: Glycine receptor subunit beta, Glycine receptor subunit alpha-1Synonyms: Glycine receptor 48 kDa subunit, Glycine receptor 58 kDa subunit
  9. Target

    Sphingosine 1-phosphate receptor 1

    go.drugbank.com/bio_entities/BE0008652
    TargetHumans

    G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins.

    Polypeptides: Sphingosine 1-phosphate receptor 1Synonyms: S1P receptor 1, S1P receptor Edg-1
  10. Target

    G protein-coupled receptor 12

    go.drugbank.com/bio_entities/BE0009153
    TargetHumans

    Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production (PubMed:36593162). … Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (By similarity).

    Polypeptides: G protein-coupled receptor 12Function: G protein-coupled receptor activity