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Tyrosine-protein kinase receptor TYRO3
go.drugbank.com/bio_entities/BE0009404TargetHumansReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6.
Polypeptides: Tyrosine-protein kinase receptor TYRO3Ephrin type-A receptor 1
go.drugbank.com/bio_entities/BE0009436TargetHumansThe signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. … Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-A receptor 1Synonyms: Tyrosine-protein kinase receptor EPH, Erythropoietin-producing hepatoma receptorEphrin type-A receptor 8
go.drugbank.com/bio_entities/BE0009440TargetHumansReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Polypeptides: Ephrin type-A receptor 8Synonyms: Tyrosine-protein kinase receptor EEKEphrin type-B receptor 1
go.drugbank.com/bio_entities/BE0009441TargetHumansCognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. … Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-B receptor 1Synonyms: Tyrosine-protein kinase receptor EPH-2NT-3 growth factor receptor
go.drugbank.com/bio_entities/BE0009501TargetHumansReceptor tyrosine kinase involved in nervous system and probably heart development.
Polypeptides: NT-3 growth factor receptorSynonyms: Neurotrophic tyrosine kinase receptor type 3Receptor for retinol uptake STRA6
go.drugbank.com/bio_entities/BE0009879TransporterHumansFunctions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding prot...
Polypeptides: Receptor for retinol uptake STRA6Synonyms: Retinol-binding protein receptor STRA6Sphingosine 1-phosphate receptor 4
go.drugbank.com/bio_entities/BE0009882TargetHumansFunctions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). … G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production.
Polypeptides: Sphingosine 1-phosphate receptor 4Synonyms: S1P receptor 4, S1P receptor Edg-6C5a anaphylatoxin chemotactic receptor 1
go.drugbank.com/bio_entities/BE0010095TargetHumansReceptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, … The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events
Polypeptides: C5a anaphylatoxin chemotactic receptor 1Synonyms: C5a anaphylatoxin chemotactic receptorInterferon alpha/beta receptor (IFNAR)
go.drugbank.com/bio_entities/BE0010136TargetHumansTogether with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461 … Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity)
Polypeptides: Interferon alpha/beta receptor 1, Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 1, IFN-alpha/beta receptor 2Interleukin-1 receptor-like 2
go.drugbank.com/bio_entities/BE0010198TargetHumansReceptor for interleukin-36 (IL36A, IL36B and IL36G). … After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways
Polypeptides: Interleukin-1 receptor-like 2Synonyms: IL-36 receptor, Interleukin-1 receptor-related protein 2