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Displaying results 971 - 980 of 3387 in total
  1. Target

    Tumor necrosis factor receptor superfamily member 10A

    go.drugbank.com/bio_entities/BE0010564
    TargetHumans

    Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor.

    Polypeptides: Tumor necrosis factor receptor superfamily member 10ASynonyms: Death receptor 4, TRAIL receptor 1
  2. Target

    Inactive tyrosine-protein kinase transmembrane receptor ROR1

    go.drugbank.com/bio_entities/BE0010828
    TargetHumans

    Receptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).

    Polypeptides: Inactive tyrosine-protein kinase transmembrane receptor ROR1Synonyms: Neurotrophic tyrosine kinase, receptor-related 1
  3. Target

    Macrophage scavenger receptor types I and II

    go.drugbank.com/bio_entities/BE0010942
    TargetHumans

    Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.

    Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Scavenger receptor class A member 1, Macrophage acetylated LDL receptor I and II
  4. Target

    Triggering receptor expressed on myeloid cells 2

    go.drugbank.com/bio_entities/BE0020451
    TargetHumans

    In dendritic cells, receptor of SEMA6D with PLEXNA1 as coreceptor and mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). … Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849).

    Polypeptides: Triggering receptor expressed on myeloid cells 2Synonyms: Triggering receptor expressed on monocytes 2
  5. Target

    T cell receptor beta variable 5-6

    go.drugbank.com/bio_entities/BE0023691
    TargetHumans

    V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor beta variable 5-6
  6. Drug

    Lemborexant

    go.drugbank.com/drugs/DB11951
    ApprovedInvestigational

    [L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an inability to … Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.

    Categories: Orexin Receptor Antagonists, P-glycoprotein substrates
  7. Target

    Gamma-aminobutyric acid receptor subunit alpha-2

    go.drugbank.com/bio_entities/BE0000381
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:29961870, PubMed:31032849). GABA-gated chloride channe...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-2
  8. Target

    Gamma-aminobutyric acid receptor subunit alpha-5

    go.drugbank.com/bio_entities/BE0000471
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:29961870, PubMed:30140029, PubMed:31056671). GABA-gate...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-5Synonyms: GABA(A) receptor subunit alpha-5
  9. Target

    Gamma-aminobutyric acid receptor subunit alpha-3

    go.drugbank.com/bio_entities/BE0000523
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:29053855). GABA-gated chloride channels, also named GA...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-3Synonyms: GABA(A) receptor subunit alpha-3
  10. Target

    Gamma-aminobutyric acid receptor subunit alpha-1

    go.drugbank.com/bio_entities/BE0000795
    TargetHumans

    GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity).

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1Synonyms: GABA(A) receptor subunit alpha-1